SGER: Activated Hydrogen Peroxide Detoxification of Chemical-Biological Warfare Agents

卡内基梅隆大学的Terrence J. Collins教授的这项研究得到了无机、生物无机和有机金属化学项目的支持，其目的是开发四酰胺大环铁（III）配合物（TAML活化剂），并与过氧化氢结合，以破坏污染表面上的化学和生物战争剂。这些毒剂包括有机磷酯神经毒气，如沙林毒气和VX毒气、芥菜（烷基化）化合物和生物制剂，包括细菌、病毒和毒素。这项探索性研究小额赠款支持开发一种广泛适用的净化程序，以消除各种化学和生物战剂，包括已经或可能用于恐怖主义的病毒和细菌，如炭疽。

The objective of this research by Professor Terrence J. Collins at Carnegie-Mellon University, which is supported by the Inorganic, Bioinorganic and Oganometallic Chemistry Program, is to develop tetraamidomacrocyclic iron(III) complexes (TAML activators) in conjunction with hydrogen peroxide to destroy chemical and biological warfare agents on contaminated surfaces. These agents include organophosphorous ester nerve gases such as, such as Sarin and VX, mustard (alkylating) compounds and biological agents including bacteria, virus, and toxins. This Small Grant for Exploratory Research supports the development of a widely-applicable decontaminating process to eliminate various chemical and biological warfare agents including viruses and bacteria, such as anthrax, that have been or may be used in terrorism.