SGER: Activated Hydrogen Peroxide Detoxification of Chemical-Biological Warfare Agents

SGER：生化战剂的活化过氧化氢解毒

• 批准号: 0211065
• 负责人: Terrence Collins
• 金额: $ 10万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0211065&HistoricalAwards=false
• 关键词: SGER; Activated; Hydrogen; Peroxide; Detoxification

The objective of this research by Professor Terrence J. Collins at Carnegie-Mellon University, which is supported by the Inorganic, Bioinorganic and Oganometallic Chemistry Program, is to develop tetraamidomacrocyclic iron(III) complexes (TAML activators) in conjunction with hydrogen peroxide to destroy chemical and biological warfare agents on contaminated surfaces. These agents include organophosphorous ester nerve gases such as, such as Sarin and VX, mustard (alkylating) compounds and biological agents including bacteria, virus, and toxins. This Small Grant for Exploratory Research supports the development of a widely-applicable decontaminating process to eliminate various chemical and biological warfare agents including viruses and bacteria, such as anthrax, that have been or may be used in terrorism.

卡内基-梅隆大学的特伦斯·J·柯林斯教授的这项研究得到了无机化学、生物无机化学和有机金属化学计划的支持，其目的是开发四胺大环铁(III)络合物(TAML激活剂)，与过氧化氢一起摧毁受污染表面的化学和生物战剂。这些药剂包括有机磷酯神经毒气，如沙林和VX、芥子(烷基化)化合物和包括细菌、病毒和毒素在内的生物药剂。这笔用于探索性研究的小额赠款支持开发一种广泛适用的净化程序，以消除已经或可能用于恐怖主义的各种化学和生物战剂，包括病毒和细菌，如炭疽。