Environmentally Benign and Hydrocarbon-Soluble Oxidants Based on High Valent MLTM Chemistry

9319505柯林斯卡内基梅隆大学特伦斯J.柯林斯博士，化学系，卡内基梅隆大学，是由无机，生物无机和有机化学计划的支持，研究到稳定的高价中，后过渡金属配合物的发展和化学。通过配体改性，制备出烷溶性氧化剂。将开发一系列水溶性或聚合物附着的高价钴、铜和镍氧化剂，作为商业上使用的但有毒的Cr（VI）试剂的潜在替代品。由于有证据表明Cr（V）会诱导DNA损伤，因此将评价该物质作为致癌物和诱变剂的作用。最后，开发了一系列Cu（IV）和Ni（IV）配合物作为双电子还原剂，并探索了制备Cu（V）和Ni（V）物种的可行性。 各种各样的氧化剂，在化学反应中将一个或多个电子转移到另一个物种的化合物，通常用于化学的所有领域。在这个项目中，将开发新的氧化剂，这将是更有效，更容易使用，和环境更友好的比目前使用的。由于铬通常用于氧化，因此将评估DNA与该元素的一种重要形式的相互作用。总的来说，该项目将有助于设计新的试剂，这些试剂更容易使用，毒性更小，污染更少。

9319505 Collins Carnegie Mellon Univ. Dr. Terrence J. Collins, Chemistry Department, Carnegie Mellon University, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program for research into the development and chemistry of stable high valent mid- and late- transition metal complexes. Through ligand modification, alkane soluble oxidants will be prepared. A series of water soluble or polymer attached high valent cobalt, copper, and nickel oxidants will be developed as potential replacements for commercially used, but toxic, Cr(VI) reagents. As there is evidence that Cr(V) will induce DNA damage, the role of this species as a carcinogen and mutagen will be evaluated. Finally, a series of Cu(IV) and Ni(IV) complexes will be developed as two electron reductant and the feasibility of producing Cu(V) and Ni(V) species will be explored. A wide variety of oxidants, compounds which transfer one or more electrons to another species in a chemical reaction, are used routinely in all areas of chemistry. In this project new oxidants will be developed which will be more efficient, easier to use, and environmentally more friendly than the ones which are currently employed. As chromium is commonly used in oxidations, the interactions of DNA with one important form of this element will be evaluated. Overall this project will contribute to design of new reagents which are easier to use, not as toxic, and less polluting than those which are now being used.