Environmentally Benign and Hydrocarbon-Soluble Oxidants Based on High Valent MLTM Chemistry

9319505 Collins卡内基梅隆大学化学系Terrence J. Collins博士，受无机、生物无机和有机金属化学项目支持，研究稳定的高价中、晚期过渡金属配合物的发展和化学。通过配体修饰，可以制备烷烃可溶性氧化剂。一系列水溶性或聚合物附着的高价钴、铜和镍氧化剂将被开发出来，作为商业上使用的、但有毒的Cr（VI）试剂的潜在替代品。由于有证据表明Cr(V)会引起DNA损伤，因此将对该物种作为致癌物和诱变剂的作用进行评估。最后，将开发一系列Cu（IV）和Ni（IV）配合物作为两种电子还原剂，并探索生产Cu(V)和Ni(V)的可行性。各种各样的氧化剂，即在化学反应中把一个或多个电子转移到另一种物质上的化合物，在化学的各个领域都经常使用。本项目将开发比现有氧化剂更高效、更易于使用、更环保的新型氧化剂。由于铬通常用于氧化，DNA与这种元素的一种重要形式的相互作用将被评估。总的来说，这个项目将有助于设计新的试剂，这些试剂比现在使用的试剂更容易使用，毒性更小，污染更少。

9319505 Collins Carnegie Mellon Univ. Dr. Terrence J. Collins, Chemistry Department, Carnegie Mellon University, is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program for research into the development and chemistry of stable high valent mid- and late- transition metal complexes. Through ligand modification, alkane soluble oxidants will be prepared. A series of water soluble or polymer attached high valent cobalt, copper, and nickel oxidants will be developed as potential replacements for commercially used, but toxic, Cr(VI) reagents. As there is evidence that Cr(V) will induce DNA damage, the role of this species as a carcinogen and mutagen will be evaluated. Finally, a series of Cu(IV) and Ni(IV) complexes will be developed as two electron reductant and the feasibility of producing Cu(V) and Ni(V) species will be explored. A wide variety of oxidants, compounds which transfer one or more electrons to another species in a chemical reaction, are used routinely in all areas of chemistry. In this project new oxidants will be developed which will be more efficient, easier to use, and environmentally more friendly than the ones which are currently employed. As chromium is commonly used in oxidations, the interactions of DNA with one important form of this element will be evaluated. Overall this project will contribute to design of new reagents which are easier to use, not as toxic, and less polluting than those which are now being used.