Zirconocene and Borane Chemistry Relevant to Synthesis and Catalysis

该奖项由无机化学、生物无机化学和金属有机化学项目颁发，旨在支持哥伦比亚大学化学系杰克·R·诺顿教授的研究，以促进制药业感兴趣的化合物的合成和制造。将测量锆烷对映体相互转化的速率，并开发金属氮杂环丙烷与环氧化物和氮杂环丙烷的反应。此外，还将研究类似于烯烃聚合催化剂前驱体的烷基络合物的单电子化学。本课程将探讨硼烷及相关铝氧烷的电化学性质，以确定单电子转移是否参与这些化合物对催化剂的活化。少量的还原剂对催化烯烃聚合的影响将被确定。将开发新的试剂和方法，以更好地了解和改进药物和聚合物的合成。

This award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Jack R. Norton in the Department of Chemistry at Columbia University to facilitate the synthesis and manufacture of compounds of interest to the pharmaceutical industry. The rates at which zirconaziridine enantiomers interconvert will be measured and reactions of metallaaziridines with epoxides and aziridines will be developed. In addition, the one-electron chemistry of alkyl complexes similar to those that serve as precursors for olefin polymerization catalysts will be investigated. The electrochemistry of boranes and related alumoxanes will be explored in order to determine whether single-electron transfer is involved in catalyst activation by these compounds. The effects of small amounts of reducing agents on catalytic olefin polymerization will be determined. New reagents and methods will be developed to better understand and improve the synthesis of pharmaceuticals and polymers.