Zirconocene and Borane Chemistry Relevant to Synthesis and Catalysis

与合成和催化相关的二茂锆和硼烷化学

• 批准号: 0211310
• 负责人: Jack Norton
• 金额: $ 41万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2004-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0211310&HistoricalAwards=false
• 关键词: Zirconocene; Borane; Chemistry; Relevant; Synthesis

This award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Jack R. Norton in the Department of Chemistry at Columbia University to facilitate the synthesis and manufacture of compounds of interest to the pharmaceutical industry. The rates at which zirconaziridine enantiomers interconvert will be measured and reactions of metallaaziridines with epoxides and aziridines will be developed. In addition, the one-electron chemistry of alkyl complexes similar to those that serve as precursors for olefin polymerization catalysts will be investigated. The electrochemistry of boranes and related alumoxanes will be explored in order to determine whether single-electron transfer is involved in catalyst activation by these compounds. The effects of small amounts of reducing agents on catalytic olefin polymerization will be determined. New reagents and methods will be developed to better understand and improve the synthesis of pharmaceuticals and polymers.

这个奖项由无机，生物无机和有机化学计划支持研究教授杰克R。诺顿在化学系在哥伦比亚大学，以促进合成和生产化合物的利益，制药工业。 将测量锆氮丙啶对映体相互转化的速率，并将开发金属氮丙啶与环氧化物和氮丙啶的反应。 此外，将研究类似于用作烯烃聚合催化剂的前体的烷基络合物的单电子化学。 将探讨硼烷和相关铝氧烷的电化学，以确定这些化合物的催化剂活化是否涉及单电子转移。 将测定少量还原剂对催化烯烃聚合的影响。 将开发新的试剂和方法，以更好地理解和改进药物和聚合物的合成。