Zirconocene and Borane Chemistry Relevant to Synthesis and Catalysis

该奖项由无机、生物无机和有机金属化学项目颁发，支持哥伦比亚大学化学系Jack R. Norton教授的研究，以促进制药工业感兴趣的化合物的合成和制造。测定锆氮吡啶对映体相互转化的速率，研究金属氮吡啶与环氧化物和氮吡啶的反应。此外，将研究与烯烃聚合催化剂前驱体类似的烷基配合物的单电子化学性质。硼烷和相关铝烷的电化学将被探索，以确定是否单电子转移参与催化剂活化这些化合物。研究了少量还原剂对烯烃催化聚合的影响。将开发新的试剂和方法，以更好地理解和改进药物和聚合物的合成。

This award by the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Jack R. Norton in the Department of Chemistry at Columbia University to facilitate the synthesis and manufacture of compounds of interest to the pharmaceutical industry. The rates at which zirconaziridine enantiomers interconvert will be measured and reactions of metallaaziridines with epoxides and aziridines will be developed. In addition, the one-electron chemistry of alkyl complexes similar to those that serve as precursors for olefin polymerization catalysts will be investigated. The electrochemistry of boranes and related alumoxanes will be explored in order to determine whether single-electron transfer is involved in catalyst activation by these compounds. The effects of small amounts of reducing agents on catalytic olefin polymerization will be determined. New reagents and methods will be developed to better understand and improve the synthesis of pharmaceuticals and polymers.