Electrophilic Attack on Coordinated Ligands Involved in Catalysis by Organometallic Complexes

有机金属配合物对参与催化的配位配体的亲电攻击

• 批准号: 9974464
• 负责人: Jack Norton
• 金额: $ 57万
• 依托单位: Columbia University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9974464&HistoricalAwards=false
• 关键词: Electrophilic; Attack; Coordinated; Ligands; Involved

Dr. Jack Norton of the Department of Chemistry, Columbia University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program of the Chemistry Division to (i) examine the dynamics of hydride ligand exchange with hydrogens of uncoordinated acids; (ii) search for optically active hydride complexes and explore their ability to catalyze enantioselective hydrogenation of prochiral substrates; (iii) explore insertion reactions of nitrogen- and sulfur-containing cyclic reagents into the M-C bond of zirconaaziridines, and related systems, and exploit their dynamics and configurational changes to control the stereochemistry of amino acid derivatives; and (iv) examine the likelihood that electrophilic boranes used to activate olefin polymerization catalysts can also serve as one-electron oxidants.The significance of the project is manyfold: (i) hydride acceptors from metal centers will be utilized to uncover important new methods for generating reactive cationic metal catalysts, and (ii) studies focussed at understanding the reduction and abstraction properties of fluorinated borane compounds will have a direct bearing on the development of new methods to produce polymers currently in daily production in several industrial facilities. Students and post-doctorate associates will receive excellent training in the area of catalysis and polymer precursor chemistry, the kind of training that will facilitate obtaining good industrial jobs.

美国哥伦比亚大学化学系的Jack Norton博士受化学部无机、生物无机和有机金属化学项目的支持，主要从事以下工作：(I)研究氢化物配体与非配位酸氢的交换动力学；(Ii)寻找具有光学活性的氢化物络合物并探索其催化前手性底物对映体选择性氢化的能力；(Iii)探索含氮和含硫的环状试剂在锆康氮烷及其相关体系的M-C键上的插入反应，并利用它们的动力学和构型变化来控制氨基酸衍生物的立体化学；该项目的意义是多方面的：(I)来自金属中心的氢化物受体将被用来发现产生活性阳离子金属催化剂的重要新方法，以及(Ii)专注于了解氟化硼烷化合物的还原和抽提性质的研究将直接影响目前在几个工业设施的日常生产中生产聚合物的新方法的开发。学生和博士后助理将在催化和聚合物前体化学领域接受出色的培训，这种培训将有助于获得良好的工业工作。