Stereochemistry of Nanoscale Molecules

在有机和高分子化学项目的支持下，杰伊·S·加州大学圣地亚哥分校化学系的西格尔正在研究纳米级分子的立体化学。Siegel教授正在进行代表不寻常的拓扑立体异构体的分子的合成，包括手性索烃，对映体纯D3三叶结和Borromean链接。在制备这些分子时，研究了它们不寻常的结构所产生的性质，包括高效的荧光发射。类似于咕鲁烯的碗状多环芳烃的合成以及它们的碗到碗反转动力学也在研究中。将制备这些结构的手性衍生物，并研究它们的手性和分子识别特性，包括对离子、气体和极性分子的亲和力。液晶和树枝状结构的corranulene也将被制备。分子设计，再加上化学合成，提供了最好的方法来开发真正的新分子材料。纳米级分子代表了一个相对未被探索的合成设计的化学结构家族，是经典天然产物与生物分子和聚合物之间的中间体。这一领域的设计原则仍处于起步阶段，这些化合物的三维结构（立体化学）仍然令人着迷。Jay S. Siegel是加州大学圣地亚哥分校化学系的教授，他运用实验、理论和计算技术来合成和立体化学解析纳米级分子，这些分子代表了合成有机化学系统所不能代表的各种经典立体化学，包括三叶结和Borromean链接。

With the support of the Organic and Macromolecular Chemistry Program, Professor Jay S. Siegel, of the Department of Chemistry at the University of Calfornia, San Diego, is studying the stereochemistry of nanoscale molecules. Professor Siegel is carrying out the synthesis of molecules representing unusual topological stereoisomers, including chiral catenanes, enantiopure D3 trefoil knots, and Borromean links. As these molecules are prepared, properties arising from their unusual structures, including highly efficient fluorescence emission, are studied. The synthesis of bowl-shaped polycyclic aromatic hydrocarbons similar to corranulene and the dynamics of their bowl-to-bowl inversion are also under investigation. Chiral derivatives of these structures will be prepared and their chiroptical and molecular recognition properties, including affinities for ions, gases, and polar molecules, will be studied. Liquid crystalline and dendrimeric corranulene-based structures will also be prepared.Molecular design, coupled with chemical synthesis, offers the best approach to the development of truly new molecular materials. Nanoscale molecules represent a relatively unexplored family of synthetically designed chemical structures, intermediate between classical natural products and biomolecules and polymers. Design principles for this area are still in their infancy, and the three-dimensional structures (stereochemistry) of these compounds remain fascinating. Professor Jay S. Siegel, of the Department of Chemistry at the University of California at San Diego, applies experimental, theoretical, and computational techniques to the synthesis and stereochemical elucidation of nanoscale molecules representing a variety of classical stereochemistries which are unrepresented by synthetic organic chemical systems, including trefoil knots and Borromean links.