Stereochemistry of Nanoscale Molecules

纳米级分子的立体化学

基本信息

  • 批准号:
    0213323
  • 负责人:
  • 金额:
    $ 51.5万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-08-15 至 2005-07-31
  • 项目状态:
    已结题

项目摘要

With the support of the Organic and Macromolecular Chemistry Program, Professor Jay S. Siegel, of the Department of Chemistry at the University of Calfornia, San Diego, is studying the stereochemistry of nanoscale molecules. Professor Siegel is carrying out the synthesis of molecules representing unusual topological stereoisomers, including chiral catenanes, enantiopure D3 trefoil knots, and Borromean links. As these molecules are prepared, properties arising from their unusual structures, including highly efficient fluorescence emission, are studied. The synthesis of bowl-shaped polycyclic aromatic hydrocarbons similar to corranulene and the dynamics of their bowl-to-bowl inversion are also under investigation. Chiral derivatives of these structures will be prepared and their chiroptical and molecular recognition properties, including affinities for ions, gases, and polar molecules, will be studied. Liquid crystalline and dendrimeric corranulene-based structures will also be prepared.Molecular design, coupled with chemical synthesis, offers the best approach to the development of truly new molecular materials. Nanoscale molecules represent a relatively unexplored family of synthetically designed chemical structures, intermediate between classical natural products and biomolecules and polymers. Design principles for this area are still in their infancy, and the three-dimensional structures (stereochemistry) of these compounds remain fascinating. Professor Jay S. Siegel, of the Department of Chemistry at the University of California at San Diego, applies experimental, theoretical, and computational techniques to the synthesis and stereochemical elucidation of nanoscale molecules representing a variety of classical stereochemistries which are unrepresented by synthetic organic chemical systems, including trefoil knots and Borromean links.
在有机和高分子化学项目的支持下,杰伊·S·加州大学圣地亚哥分校化学系的西格尔正在研究纳米级分子的立体化学。Siegel教授正在进行代表不寻常的拓扑立体异构体的分子的合成,包括手性索烃,对映体纯D3三叶结和Borromean链接。在制备这些分子时,研究了它们不寻常的结构所产生的性质,包括高效的荧光发射。类似于咕鲁烯的碗状多环芳烃的合成以及它们的碗到碗反转动力学也在研究中。将制备这些结构的手性衍生物,并研究它们的手性和分子识别特性,包括对离子、气体和极性分子的亲和力。液晶和树枝状结构的corranulene也将被制备。分子设计,再加上化学合成,提供了最好的方法来开发真正的新分子材料。纳米级分子代表了一个相对未被探索的合成设计的化学结构家族,是经典天然产物与生物分子和聚合物之间的中间体。这一领域的设计原则仍处于起步阶段,这些化合物的三维结构(立体化学)仍然令人着迷。Jay S. Siegel是加州大学圣地亚哥分校化学系的教授,他运用实验、理论和计算技术来合成和立体化学解析纳米级分子,这些分子代表了合成有机化学系统所不能代表的各种经典立体化学,包括三叶结和Borromean链接。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Yitzhak Tor其他文献

Thieno[3,4-emd/em]pyrimidin-4(3emH/em)-thione: an effective, oxygenation independent, heavy-atom-free photosensitizer for cancer cells
噻吩并[3,4-乙撑/乙撑]嘧啶-4(3H)-硫酮:一种有效的、不依赖氧合、无重原子的癌细胞光敏剂
  • DOI:
    10.1039/d3sc02592f
  • 发表时间:
    2023-08-23
  • 期刊:
  • 影响因子:
    7.400
  • 作者:
    Luis A. Ortiz-Rodríguez;Ye-Guang Fang;Germain Niogret;Kaivin Hadidi;Sean J. Hoehn;Heather J. Folkwein;Steffen Jockusch;Yitzhak Tor;Ganglong Cui;Liraz Levi;Carlos E. Crespo-Hernández
  • 通讯作者:
    Carlos E. Crespo-Hernández
Correction to: Surfen and oxalyl surfen decrease tau hyperphosphorylation and mitigate neuron deficits in vivo in a zebrafish model of tauopathy
  • DOI:
    10.1186/s40035-020-00220-3
  • 发表时间:
    2020-12-01
  • 期刊:
  • 影响因子:
    15.200
  • 作者:
    Seyedeh Maryam Alavi Naini;Constantin Yanicostas;Rahma Hassan-Abdi;Sébastien Blondeel;Mohamed Bennis;Ryan J. Weiss;Yitzhak Tor;Jeffrey D. Esko;Nadia Soussi-Yanicostas
  • 通讯作者:
    Nadia Soussi-Yanicostas
Novel transporters for MPS I and MPS IIIA enzyme replacement therapy
  • DOI:
    10.1016/j.ymgme.2012.11.251
  • 发表时间:
    2013-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Wenyong Tong;Stephane Sarrazin;Yitzhak Tor;Jeffrey Esko
  • 通讯作者:
    Jeffrey Esko
Designing new isomorphic fluorescent nucleobase analogues: the thieno[3,2-<em>d</em>]pyrimidine core
  • DOI:
    10.1016/j.tet.2007.01.075
  • 发表时间:
    2007-04-23
  • 期刊:
  • 影响因子:
  • 作者:
    Yitzhak Tor;Susan Del Valle;David Jaramillo;Seergazhi G. Srivatsan;Andro Rios;Haim Weizman
  • 通讯作者:
    Haim Weizman
RNA UND DIE WELT DER KLEINEN MOLEKULE
RNA与小分子世界
  • DOI:
  • 发表时间:
    1999
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yitzhak Tor
  • 通讯作者:
    Yitzhak Tor

Yitzhak Tor的其他文献

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{{ truncateString('Yitzhak Tor', 18)}}的其他基金

International Collaboration in Chemistry: Exploring the interactions between small molecules and biopolymers using localized surface plasmon resonance (LSPR) spectroscopy
国际化学合作:利用局域表面等离子共振 (LSPR) 光谱探索小分子和生物聚合物之间的相互作用
  • 批准号:
    1303554
  • 财政年份:
    2013
  • 资助金额:
    $ 51.5万
  • 项目类别:
    Standard Grant

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  • 批准号:
    2040086
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    2021
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Measuring Nanoscale Exciton Motion & Annihilation in Single Molecules with Photon Statistics
测量纳米级激子运动
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    EP/V004921/1
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Dielectric polarization properties of biological molecules on the nanoscale
纳米尺度生物分子的介电极化特性
  • 批准号:
    2297532
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    2019
  • 资助金额:
    $ 51.5万
  • 项目类别:
    Studentship
CAREER: Multi-stimuli Responsive DNA-Nanoshells - Compartmentalizing Molecules at the Nanoscale for Enhanced Reaction Selectivity and Sensitivity
职业:多重刺激响应 DNA 纳米壳 - 在纳米尺度上划分分子以增强反应选择性和灵敏度
  • 批准号:
    1847869
  • 财政年份:
    2019
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    $ 51.5万
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    2017
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Nanoscale toolset for formatiing and visualizing single molecules
用于形成和可视化单分子的纳米级工具集
  • 批准号:
    501971-2016
  • 财政年份:
    2016
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    $ 51.5万
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    Idea to Innovation
Massively parallel linearization and chemical treatment of DNA molecules using tunable nanoscale confinement
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REU Site: Nanoscale Assembly of Molecules and Materials at Indiana University
REU 站点:印第安纳大学分子和材料的纳米级组装
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    1460720
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Nanoscale carbon electronics to probe charge transfer mechanisms in individual organic and biological molecules
纳米级碳电子器件用于探测单个有机和生物分子中的电荷转移机制
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    491390-2015
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    2015
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tudy of pathological mechanism underlying autism by focusing on nanoscale distribution of synaptic molecules
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