Applications of Irreversible Photooxidation
不可逆光氧化的应用
基本信息
- 批准号:0213445
- 负责人:
- 金额:$ 30.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-08-01 至 2005-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
With the support of the Organic and Macromolecular Chemistry Program, Professor Ian Gould, of the Department of Chemistry and Biochemistry at Arizona State University, is studying applications of irreversible photooxidation in the elucidation of the mechanisms of oxidative processes in DNA. N-O bond cleavage of N-alkoxyheterocycles affords the radical cation of the parent heterocycle and an alkoxy radical. These irreversible photocleavage reactions allow exploration of the reaction chemistry of each of these reactive species. Following elucidation of the mechanisms and scope of the photochemistry of N-alkoxyheterocycles, Professor Gould will determine the oxidation potentials and lifetimes of purine radical cations in duplex DNA and explore the factors controlling their reactivity. Finally, oxidative damage in DNA will be studied using a mechanistic approach based on accurate measurements of quantum yields, quantifying the absolute and relative efficiencies of single-strand cleavage via one-electron oxidation of purine bases and via radical abstraction from the sugar backbone.Oxidation of DNA leads to reactive intermediate species. Exploration of the fundamental reaction chemistry of these reactive intermediates will lead to a more detailed understanding of oxidative processes which are of central importance in DNA chemistry and biochemistry. By developing unique reagents allowing the efficient formation of oxidized DNA species, Professor Ian Gould, of the Department of Chemistry and Biochemistry at Arizona State University, is exploring the reaction chemistry of these important but only transiently existent reactive intermediates.
在有机和高分子化学项目的支持下,亚利桑那州立大学化学和生物化学系的 Ian Gould 教授正在研究不可逆光氧化在阐明 DNA 氧化过程机制中的应用。 N-烷氧基杂环的N-O键断裂提供母体杂环的自由基阳离子和烷氧基。这些不可逆的光裂解反应允许探索每种反应物质的反应化学。在阐明 N-烷氧基杂环光化学的机制和范围后,Gould 教授将确定双链 DNA 中嘌呤自由基阳离子的氧化电位和寿命,并探索控制其反应性的因素。最后,将使用一种基于量子产率精确测量的机械方法来研究 DNA 中的氧化损伤,通过嘌呤碱基的单电子氧化和从糖主链中的自由基提取来量化单链切割的绝对和相对效率。DNA 的氧化会产生反应性中间体。探索这些反应中间体的基本反应化学将有助于更详细地了解氧化过程,这在 DNA 化学和生物化学中至关重要。亚利桑那州立大学化学与生物化学系的 Ian Gould 教授通过开发能够有效形成氧化 DNA 物质的独特试剂,正在探索这些重要但短暂存在的反应中间体的反应化学。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ian Gould其他文献
N-Terminal domains of cardiac troponin-I modulate thin filament structure
- DOI:
10.1016/j.bpj.2021.11.2535 - 发表时间:
2022-02-11 - 期刊:
- 影响因子:
- 作者:
Elumalai Pavadai;Michael J. Rynkiewicz;Zeyu Yang;Ian Gould;Steven B. Marston;William Lehman - 通讯作者:
William Lehman
Browning reactions during storage of low‐moisture Australian sultanas: Evidence for arginine‐mediated Maillard reactions
低水分澳大利亚葡萄干储存期间的褐变反应:精氨酸介导的美拉德反应的证据
- DOI:
10.1111/j.1755-0238.2004.tb00018.x - 发表时间:
2004 - 期刊:
- 影响因子:2.8
- 作者:
D. Frank;Ian Gould;M. Millikan - 通讯作者:
M. Millikan
The Molecular Defects in Ca<sup>2+</sup> Regulation due to Mutations that Cause Hypertrophic Cardiomyopathy can be Reversed by Small Molecules that Bind to Troponin
- DOI:
10.1016/j.bpj.2017.11.253 - 发表时间:
2018-02-02 - 期刊:
- 影响因子:
- 作者:
Steven B. Marston;Andrew E. Messer;Juan Eiros-Zamora;Ian Gould;Maria Papadaki;Afnan Choudry;Alice Sheehan - 通讯作者:
Alice Sheehan
ECAP-controlled closed-loop versus open-loop SCS for the treatment of chronic pain: 36-month results of the EVOKE blinded randomized clinical trial
ECAP 控制的闭环与开环 SCS 治疗慢性疼痛:EVOKE 盲法随机临床试验的 36 个月结果
- DOI:
10.1136/rapm-2023-104751 - 发表时间:
2023 - 期刊:
- 影响因子:5.1
- 作者:
N. Mekhail;Robert M. Levy;T. Deer;L. Kapural;Sean Li;K. Amirdelfan;J. Pope;C. Hunter;S. Rosen;Shrif J Costandi;S. Falowski;A. Burgher;Christopher A. Gilmore;Farooq A Qureshi;P. Staats;J. Scowcroft;Tory McJunkin;J. Carlson;Christopher K. Kim;Michael I. Yang;T. Stauß;E. Petersen;Jonathan M. Hagedorn;R. Rauck;J. Kallewaard;G. Baranidharan;R.S. Taylor;L. Poree;Dan Brounstein;R. Duarte;Gerrit E. Gmel;R. Gorman;Ian Gould;Erin Hanson;D. Karantonis;Abeer Khurram;Angela Leitner;Dave Mugan;Milan Obradovic;Zhonghua Ouyang;John L. Parker;P. Single;Nicole Soliday - 通讯作者:
Nicole Soliday
EE108 Updated Budget Impact Analysis of Vibegron for the Treatment of Overactive Bladder in the United States
- DOI:
10.1016/j.jval.2025.04.400 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:6.000
- 作者:
Ian Gould;Jeff Lee;Jeffrey Nesheim;Adam Carrera - 通讯作者:
Adam Carrera
Ian Gould的其他文献
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{{ truncateString('Ian Gould', 18)}}的其他基金
An Intelligent Tutoring System for Organic Chemistry
有机化学智能教学系统
- 批准号:
1525197 - 财政年份:2015
- 资助金额:
$ 30.31万 - 项目类别:
Standard Grant
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