Model Studies of Reversibly Interacting Surfaces

可逆相互作用表面的模型研究

• 批准号: 0214146
• 负责人: Kenneth Shull
• 金额: $ 30.9万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0214146&HistoricalAwards=false
• 关键词: Model; Studies; Reversibly; Interacting; Surfaces

The PI proposes to study interactions between surfaces and interfaces to which well-characterized distributions of adhesion molecules have been added. The molecules are based on block copolymers consisting of hydrophobic and hydrophilic portions that are localized at a solid/liquid or liquid/liquid interface. Experiments are designed to study a variety of attractive interactions between two such interfaces in aqueous media. These attractive interactions are reversible, and result from specific interactions between functional groups attached to the hydrophilic portions of the block copolymers. Proposed experiments include studies of hydrophobic interactions between functional groups that are attached to the ends of the polymer chains, hydrogen-bonding interactions between functional groups that are attached to the ends of the polymer chains, and strong hydrogen-bonding interactions between a model receptor/ligand pair that has been well-characterized by the biophysics community. The experiments will determine the ways that collective forces from individual adhesion molecules result in quantifiable attractive interactions between surfaces bearing multiple adhesive groups. The proposed research will define the role of the surface, the effects of spatial distribution of adhesive molecules (uniformly distributed or clustered) and the lateral mobility of the adhesive molecules in the plane interface. A series of contact experiments have been designed that are sensitive to interfacial interaction energies spanning several orders to magnitude.The research provides a necessary link between the molecular-level information that is becoming increasingly available as a result of recent advances in nanoscience and nanotechnology, and the information that is needed for the appropriate design of biomaterials or self-assembling systems, where the relevant length scales are often in the micron range. Development of experimental methods and theoretical models that can be utilized to make this connection between 'nanoscopic' and 'microscopic' properties will be an important outcome of this research. A micromechanics laboratory with enhanced capabilities for studies of 'soft' materials will also be available to scientists throughout Northwestern University and the their collaborators. In addition, graduate and undergraduate students will be trained in aspects of surface science and mechanics, and in both physical and chemical aspects of polymer science.

PI建议研究表面和界面之间的相互作用，其中添加了粘附分子的良好表征分布。 这些分子是基于由疏水和亲水部分组成的嵌段共聚物，这些部分位于固/液或液/液界面。 实验的目的是研究各种有吸引力的相互作用在水介质中的两个这样的界面。 这些有吸引力的相互作用是可逆的，并且是由连接到嵌段共聚物的亲水部分的官能团之间的特定相互作用产生的。 建议的实验包括研究的疏水相互作用的官能团，连接到聚合物链的末端，连接到聚合物链的末端的官能团之间的氢键相互作用，和强的氢键之间的相互作用的模型受体/配体对已被充分表征的生物物理学社区。 这些实验将确定来自单个粘附分子的集体力导致承载多个粘附基团的表面之间的可量化的吸引力相互作用的方式。 拟议的研究将定义的表面的作用，粘合剂分子的空间分布（均匀分布或集群）和粘合剂分子在平面界面的横向流动性的影响。 设计了一系列接触实验，对跨越几个数量级的界面相互作用能敏感。这项研究提供了分子水平信息之间的必要联系，这些信息由于纳米科学和纳米技术的最新进展而变得越来越容易获得，以及生物材料或自组装系统的适当设计所需的信息，其中相关的长度尺度通常在微米范围内。 实验方法和理论模型的发展，可以用来使这种连接之间的“纳米”和“微观”属性将是这项研究的重要成果。 西北大学的科学家及其合作者也将获得一个具有增强的“软”材料研究能力的微力学实验室。 此外，研究生和本科生将在表面科学和力学方面以及聚合物科学的物理和化学方面进行培训。