SBIR Phase I: A Novel Resonant-Enhanced Crystallization (REC) Process

SBIR 第一阶段：新型共振增强结晶 (REC) 工艺

• 批准号: 0214760
• 负责人: Fangxiao Yang
• 金额: $ 10万
• 依托单位: RESODYN CORPORATION
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0214760&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Resonant; Enhanced

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a novel Resonant-Enhanced Crystallization (REC) Process. REC technology is similar to conventional impeller stirring crystallization but with enhanced mass and heat transfer, low shear or reduced crystal breakage, and improved crystal size distribution. Purification and separation by crystallization is a multicomponent mass transfer phenomenon of the crystallizing solute and impurity solutes. Mass and heat transfer in crystallization process are key factors affecting crystal growth rate, size distribution and habit. However, in conventional crystallizers, the mass transfer coefficient is maximized when crystals are in their terminal velocity and increased agitation results in significant crystal breakage. The proposed technology will further increase mass transfer even in cases where crystals are in suspended status. Due to the low shear associated with the acoustic agitation, crystal breakage will be minimal. The second nucleation will also be reduced and therefore, crystal size distribution will be improved. The objective of this proposed research is to incorporate low-frequency acoustic agitation to the crystallization process to greatly enhance mass and heat transfer. This is expected to improve crystal growth rate, size distribution and quality. The commercial applications of this project are in the area of pharmaceutical separation and purification.

这个小企业创新研究（SBIR）第一阶段项目提出开发一种新型的共振增强结晶（REC）工艺。REC技术类似于传统的叶轮搅拌结晶，但具有增强的传质和传热、低剪切或减少的晶体破碎以及改善的晶体尺寸分布。结晶提纯分离是结晶溶质与杂质溶质的多组分传质现象。结晶过程中的传质和传热是影响晶体生长速率、粒度分布和晶习的关键因素。然而，在常规结晶器中，当晶体处于其终端速度时，传质系数最大化，并且增加的搅拌导致显著的晶体破碎。即使在晶体处于悬浮状态的情况下，所提出的技术也将进一步增加传质。由于与声搅动相关的低剪切，晶体破碎将是最小的。二次成核也将减少，因此，晶体尺寸分布将得到改善。这项研究的目的是将低频声搅拌结晶过程中，大大提高质量和传热。这有望改善晶体生长速率、尺寸分布和质量。该项目的商业应用是在药物分离和纯化领域。