Purchase of an EPR Spectrometer

购买 EPR 光谱仪

• 批准号: 0215926
• 负责人: Gary Brudvig
• 金额: $ 28.83万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0215926&HistoricalAwards=false
• 关键词: Purchase; EPR; Spectrometer

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Yale University will acquire an Electron Paramagnetic Resonance (EPR) Spectrometer. The new instrument will support the research of major users in the Chemistry, Chemical Engineering, and Molecular Biophysics and Biochemistry Departments. Some of the studies that will exploit this instrument include a) EPR studies of photosystem II and Mn model complexes; b) site directed spin labeling studies of protein secondary structure; c) de novo design of metal ion binding sites in proteins; d) bioinorganic studies of actIV cyclase and transition metal uptake; e) characterization of metal oxide catalysts; and f) EPR studies of RNase P. An electron paramagnetic resonance (EPR) spectrometer is an instrument used to obtain information about the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals which are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will have an impact in a number of areas, in particular biological chemistry.

有了这项来自主要研究仪器（MRI）计划的奖项，耶鲁大学化学系将获得一台电子顺磁共振（EPR）光谱仪。 新仪器将支持化学，化学工程，分子生物物理和生物化学部门的主要用户的研究。 将利用这一仪器的一些研究包括：a）光系统II和Mn模型复合物的EPR研究; B）蛋白质二级结构的定点自旋标记研究; c）蛋白质中金属离子结合位点的从头设计; d）actIV环化酶和过渡金属吸收的生物无机研究; e）金属氧化物催化剂的表征;和f）RNase P的EPR研究。电子顺磁共振（EPR）光谱仪是用于获得关于分子的分子和电子结构的信息的仪器。它还可以用来获得有关自由基的寿命的信息，这些自由基通常是肿瘤生长和/或各种化学反应的起始所必需的。 这些研究将在一些领域产生影响，特别是生物化学。