Purchase of an EPR Spectrometer for Research and Education

购买 EPR 光谱仪用于研究和教育

• 批准号: 1048623
• 负责人: Mark Cracolice
• 金额: $ 22.19万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-15 至 2013-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1048623&HistoricalAwards=false
• 关键词: Purchase; EPR; Spectrometer; Research; Education

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professor Mark Cracolice and colleagues Bruce Bowler, Michele McGuirl, Edward Rosenberg and Valeriy Smirnov from University of Montana will acquire an X-band EPR spectrometer. The proposal is aimed at enhancing research training and education at all levels, especially in areas of study such as (a) the role of protein dynamics in folding and function, (b) characterization of amino acid radicals and copper binding to deseases states of prions, (c) oxidation of protein-bound amino acid residues, (d) surface-immobilized luminescent and redox-active ruthenium complexes, (e) radicals produced during metabolism of chromium(V and VI), and (f) mechamism of Ric-8A-catalyzed guanine nucleotide exchange at heterotrimeric G protein alpha subunits.An EPR spectrometer yields detailed information on the geometric and electronic structure of molecular and solid state materials. It may also be used to obtain information about the lifetimes of free radicals, short-lived, highly reactive species involved in valuable chemical transformations as well as the initiation of pathological tumor growth. These studies will impact a number of areas, from the synthesis of inorganic and organic molecules to the development of new solid state materials to compounds of biological interest. Employing examples inspired from ongoing research, this instrument will be an integral part of research and teaching at the undergraduate and graduate levels.

凭借化学研究仪器和设施：部门多用户仪器计划（CRIF：MU）的这一奖项，来自蒙大拿大学的Mark Cracolice教授和同事布鲁斯鲍勒，米歇尔麦奎尔，爱德华罗森伯格和Valeriy Smirnov将获得X波段EPR光谱仪。该提案旨在加强各级的研究、培训和教育，特别是在以下研究领域：（a）蛋白质动力学在折叠和功能中的作用，（B）朊病毒疾病状态的氨基酸自由基和铜结合特性，（c）蛋白质结合氨基酸残基的氧化，（d）表面固定的发光和氧化还原活性钌络合物，（e）铬（V和VI）代谢过程中产生的自由基，和（f）Ric-8A催化的鸟嘌呤核苷酸在异源三聚体G蛋白α亚基处交换的机制。它也可用于获得有关自由基寿命的信息，这些自由基是参与有价值的化学转化以及病理性肿瘤生长起始的短寿命、高反应性物种。这些研究将影响许多领域，从无机和有机分子的合成到新固态材料的开发，再到生物学化合物。从正在进行的研究启发的例子，这个工具将是在本科和研究生水平的研究和教学的一个组成部分。