Purchase of an Electron Paramagnetic Resonance (EPR) Spectrometer

该奖项来自化学研究仪器和设施计划，将帮助加州理工学院化学与化学工程系的教师购买电子顺磁共振 (EPR) 光谱仪。 新仪器将支持六大用户的研究。 EPR 光谱学将发挥重要作用的研究项目包括： 1) 自由基与 DNA 的相互作用； 2）碳氢化合物氧化的有机金属方法； 3）金属蛋白的生物物理研究； 4）血红素蛋白氧活化的研究； 5）双核金属配合物中的长程电子转移； 6）铁和铜蛋白质中的电子转移过程； 7）电子转移触发蛋白质折叠； 8) 多肽基序作为金属阳离子传感平台的研究； 9）寡糖基转移酶的研究。电子顺磁共振（EPR）光谱仪是一种用于获取有关分子的分子和电子结构信息的仪器。它还可用于获取有关自由​​基寿命的信息，自由基对于肿瘤生长和/或各种化学反应的启动通常至关重要。

This award from the Chemistry Research Instrumentation and Facilities Program will assist faculty in the Division of Chemistry and Chemical Engineering at the California Institute of Technology to acquire an Electron Paramagnetic Resonance (EPR) Spectrometer. The new instrument will support the research of six major users. Among the research programs in which EPR spectroscopy will play a vital role are: 1) interactions of radicals with DNA; 2) organometallic approaches to hydrocarbon oxidations; 3) biophysical investigations of metalloproteins; 4) studies of oxygen activation in heme proteins; 5) long-range electron transfer in binuclear metal complexes; 6) electron transfer process in iron and copper proteins; 7) electron transfer triggered protein folding; 8) studies of polypeptide motifs as platforms for metal cation sensing; and 9) investigations of the enzyme oligosaccharyl transferase.An electron paramagnetic resonance (EPR) spectrometer is an instrument used to obtain information about the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals which are often essential for the initiation of tumor growth and/or a variety of chemical reactions.