Purchase of an Electron Paramagnetic Resonance (EPR) Spectrometer

购买电子顺磁共振 (EPR) 能谱仪

• 批准号: 9808604
• 负责人: Peter Dervan
• 金额: $ 16.85万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-15 至 1999-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9808604&HistoricalAwards=false
• 关键词: Purchase; Electron; Paramagnetic; Resonance; EPR

This award from the Chemistry Research Instrumentation and Facilities Program will assist faculty in the Division of Chemistry and Chemical Engineering at the California Institute of Technology to acquire an Electron Paramagnetic Resonance (EPR) Spectrometer. The new instrument will support the research of six major users. Among the research programs in which EPR spectroscopy will play a vital role are: 1) interactions of radicals with DNA; 2) organometallic approaches to hydrocarbon oxidations; 3) biophysical investigations of metalloproteins; 4) studies of oxygen activation in heme proteins; 5) long-range electron transfer in binuclear metal complexes; 6) electron transfer process in iron and copper proteins; 7) electron transfer triggered protein folding; 8) studies of polypeptide motifs as platforms for metal cation sensing; and 9) investigations of the enzyme oligosaccharyl transferase.An electron paramagnetic resonance (EPR) spectrometer is an instrument used to obtain information about the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals which are often essential for the initiation of tumor growth and/or a variety of chemical reactions.

化学研究仪器和设施计划的这一奖项将帮助加州理工学院化学和化学工程系的教师获得电子顺磁共振（EPR）光谱仪。 新仪器将支持六个主要用户的研究。 EPR波谱将在以下研究项目中发挥重要作用：1）自由基与DNA的相互作用; 2）碳氢化合物氧化的有机金属方法; 3）金属蛋白的生物物理研究; 4）血红素蛋白中氧活化的研究; 5）双核金属配合物中的远程电子转移; 6）铁和铜蛋白中的电子转移过程; 7）电子转移触发蛋白质折叠; 8）多肽基序作为金属阳离子传感平台的研究; 9）寡糖基转移酶的研究。电子顺磁共振（EPR）光谱仪是一种用于获得分子和分子电子结构信息的仪器。它还可以用来获得有关自由基的寿命的信息，这些自由基通常是肿瘤生长和/或各种化学反应的起始所必需的。