Protein Kinase Resource

蛋白激酶资源

• 批准号: 0217951
• 负责人: Michael Gribskov
• 金额: $ 118.41万
• 依托单位: University of California-San Diego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2005-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0217951&HistoricalAwards=false
• 关键词: Protein; Kinase; Resource

The majority of biological databases today are broad, but shallow, covering large amounts of material but in a relatively cursory way. These are essential resources as scientists use molecular biological techniques to develop a catalog of the molecules founds in living cell. Now, it is time to move beyond simply cataloguing the molecules of a cell toward the time for understanding the dynamic interactions between molecules within a cell. This level of understanding requires a different kind of database, one that links together sequence, genetics, structure and function to create a deeper resource. The existing Protein Kinase Resource (PKR, http://pkr.sdsc.edu) will be extended to create a resource from which both novices and experts can learn about protein kinases, an important family of enzymes that play roles in processes as diverse as human disease and crop production. From a technical standpoint, the resource will integrate data from a variety of existing resources in ways not previously achieved. The integration at UCSD provides a location for developing detailed and well defined application program interfaces (APIs) that will allow these resources to interoperate. It will deliver both content and technological advances in the field of biological databases. All data, software and specifications will be publicly available. Beyond students involved in the research, workshops will provide instruction in community annotation of kinases using the PKR and ways to adapt the database for other uses. Modules of the database and APIs will enable the utilization of this work by other groups interested in other enzyme families.

今天的大多数生物数据库都很广泛，但很肤浅，涵盖了大量的材料，但相对粗略。 这些是科学家利用分子生物学技术开发活细胞中发现的分子目录的重要资源。 现在，是时候超越简单地对细胞分子进行编目，了解细胞内分子之间的动态相互作用了。 这种理解水平需要一种不同类型的数据库，将序列，遗传学，结构和功能联系在一起，以创建更深层次的资源。 现有的蛋白激酶资源（PKR，http://pkr.sdsc.edu）将被扩展，以创建一个资源，新手和专家都可以从中了解蛋白激酶，一个重要的酶家族，在人类疾病和作物生产等多种过程中发挥作用。 从技术角度来看，该资源将以以前没有实现的方式整合来自各种现有资源的数据。 UCSD的集成为开发详细且定义良好的应用程序接口（API）提供了一个位置，这些API将允许这些资源进行互操作。 它将提供生物数据库领域的内容和技术进步。 所有数据、软件和规格都将公开提供。 除了参与研究的学生，研讨会将提供使用PKR的激酶社区注释的指导，以及如何将数据库用于其他用途。 数据库和API的模块将使对其他酶家族感兴趣的其他小组能够利用这项工作。