Protein Kinase Resource

今天大多数的生物数据库是广泛的，但浅，覆盖了大量的材料，但在一个相对粗略的方式。这些都是必不可少的资源，因为科学家们使用分子生物学技术来开发活细胞中发现的分子目录。现在，是时候超越简单地对细胞分子进行编目，转而了解细胞内分子之间的动态相互作用了。这种程度的理解需要一种不同的数据库，一种将序列、基因、结构和功能联系在一起的数据库，以创建更深层次的资源。现有的蛋白激酶资源（PKR, http://pkr.sdsc.edu）将被扩展，以创建一个资源，新手和专家都可以从中了解蛋白激酶，这是一个重要的酶家族，在人类疾病和作物生产等多种过程中发挥作用。从技术角度来看，该资源将以前所未有的方式整合来自各种现有资源的数据。UCSD的集成为开发详细且定义良好的应用程序接口（api）提供了一个位置，该接口将允许这些资源进行互操作。它将提供生物数据库领域的内容和技术进步。所有数据、软件和规格都将公开。除了参与研究的学生外，研讨会还将提供使用PKR对激酶进行社区注释的指导，以及如何使数据库适应其他用途。数据库和api的模块将使对其他酶家族感兴趣的其他小组能够利用这项工作。

The majority of biological databases today are broad, but shallow, covering large amounts of material but in a relatively cursory way. These are essential resources as scientists use molecular biological techniques to develop a catalog of the molecules founds in living cell. Now, it is time to move beyond simply cataloguing the molecules of a cell toward the time for understanding the dynamic interactions between molecules within a cell. This level of understanding requires a different kind of database, one that links together sequence, genetics, structure and function to create a deeper resource. The existing Protein Kinase Resource (PKR, http://pkr.sdsc.edu) will be extended to create a resource from which both novices and experts can learn about protein kinases, an important family of enzymes that play roles in processes as diverse as human disease and crop production. From a technical standpoint, the resource will integrate data from a variety of existing resources in ways not previously achieved. The integration at UCSD provides a location for developing detailed and well defined application program interfaces (APIs) that will allow these resources to interoperate. It will deliver both content and technological advances in the field of biological databases. All data, software and specifications will be publicly available. Beyond students involved in the research, workshops will provide instruction in community annotation of kinases using the PKR and ways to adapt the database for other uses. Modules of the database and APIs will enable the utilization of this work by other groups interested in other enzyme families.