ITR: Discovering Regulatory Elements in Biological Sequences

ITR：发现生物序列中的调控元件

• 批准号: 0218798
• 负责人: Martin Tompa
• 金额: $ 49.6万
• 依托单位: University of Washington
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0218798&HistoricalAwards=false
• 关键词: ITR; Discovering; Regulatory; Elements; Biological

An important and challenging question currently facing biologists is the identification of binding sites in DNA. These regulatory elements are for the proteins that are involved in the regulation of genes. The appropriate computational tools can be extremely valuable for pruning the search space of experiments, efficiently suggesting potential regulatory elements on which to focus limited laboratory resources. As more related genomes are sequenced and our understanding of regulatory relationships among genes, improves, a novel problem arises that is addressed here. Namely, the data to be analyzed will often be heterogeneous, a collection of co-regulated genes from one species together with their orthologous, i.e., corresponding, genes in several related species. This project will design, implement, and test algorithms for this novel problem and related issues in the discovery of regulatory elements. All software will be made freely available on the Internet.

目前生物学家面临的一个重要而具有挑战性的问题是DNA结合位点的识别。 这些调控元件是针对参与基因调控的蛋白质的。 适当的计算工具可以是非常有价值的修剪实验的搜索空间，有效地建议潜在的监管要素，集中有限的实验室资源。 随着更多相关基因组的测序和我们对基因间调控关系的理解的提高，这里提出了一个新的问题。 也就是说，待分析的数据通常是异质的，来自一个物种的共调节基因的集合及其同源性，即，在几个相关物种中的相应基因。 这个项目将设计，实施和测试算法，这个新的问题和相关的问题，在发现监管要素。所有软件都将在互联网上免费提供。