SGER: Effect of Breakage on Crystal Shape Distribution in a Stirred Vessel

摘要颗粒的形状和大小分布等基本性质对各种化学和制药应用中的颗粒加工有重要影响。例如，制药片剂生产中使用的晶体的形状和大小分布对产品的压实性和溶解性有很大的影响。本提案的重点是了解和建模在各种应用中由于干晶体破碎而导致的尺寸和形状分布的变化。该提案的目的是研究系统操作条件对由于破碎而导致的晶体形状分布的影响，并开发一种新的方法来定量测量由于破碎而导致的搅拌容器中颗粒形状和大小的变化。利用搅拌槽获得不同工艺参数下的破碎率数据。利用这些数据建立新的有效的多维人口平衡模型，以适应大小和形状分布的变化。

ABSTRACTBasic properties such as the particle shape and size distribution have significant influence on the processing of particulate in various chemical and pharmaceutical applications. For example, the shape and size distribution of crystals used in pharmaceutical tablet production have a strong influence on compaction and dissolution properties of the product. This proposal focuses on understanding and modeling the variation in the size and shape distribution due to breakage of dry crystals in various applications. The objectives of the proposal are to investigate the effect of the system operating conditions on crystal shape distribution due to breakage and to develop a novel procedure quantitatively measure changes in particle shape and size in a stirred vessel due to breakage. A stirred tank is used to obtain data for the rate of breakage in terms of various process parameters. The data is used to establish new and effective models for multidimensional population balance for the variation in size and shape distribution.