SGER: Effect of Breakage on Crystal Shape Distribution in a Stirred Vessel

SGER：搅拌容器中破碎对晶体形状分布的影响

• 批准号: 0225700
• 负责人: Priscilla Hill
• 金额: $ 6万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0225700&HistoricalAwards=false
• 关键词: SGER; Effect; Breakage; Crystal; Shape

ABSTRACTBasic properties such as the particle shape and size distribution have significant influence on the processing of particulate in various chemical and pharmaceutical applications. For example, the shape and size distribution of crystals used in pharmaceutical tablet production have a strong influence on compaction and dissolution properties of the product. This proposal focuses on understanding and modeling the variation in the size and shape distribution due to breakage of dry crystals in various applications. The objectives of the proposal are to investigate the effect of the system operating conditions on crystal shape distribution due to breakage and to develop a novel procedure quantitatively measure changes in particle shape and size in a stirred vessel due to breakage. A stirred tank is used to obtain data for the rate of breakage in terms of various process parameters. The data is used to establish new and effective models for multidimensional population balance for the variation in size and shape distribution.

在各种化学和制药应用中，颗粒的基本性质，如颗粒形状和粒度分布，对颗粒的加工有重要影响。例如，药物片剂生产中使用的晶体的形状和尺寸分布对产品的致密性和溶出性有很大影响。这项建议侧重于理解和模拟在各种应用中由于干晶破裂而引起的尺寸和形状分布的变化。该方案的目的是研究系统操作条件对破碎引起的晶体形状分布的影响，并开发一种新的方法来定量测量搅拌容器中由于破碎引起的颗粒形状和大小的变化。搅拌槽用来获得各种工艺参数下的破碎率数据。利用这些数据建立了大小和形状分布变化的多维种群平衡的新的有效模型。