Thermal Characterization Equipment for Diverse Particulate Materials Research and Education

用于各种颗粒材料研究和教育的热表征设备

• 批准号: 0933493
• 负责人: Priscilla Hill
• 金额: $ 10万
• 依托单位: Mississippi State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0933493&HistoricalAwards=false
• 关键词: Thermal; Characterization; Equipment; Diverse; Particulate

0933493HillThe objective of this equipment proposal is to acquire a suite of thermal characterization instrumentation including a modulated differential scanning calorimeter (MDSC), a simultaneous thermal analyzer (STA) that includes DSC and thermogravimetric analysis (TGA), and a TGA-IR interface accessory. The combined features of these instruments will allow for high sensitivity, high resolution, differentiation of complex thermal events, and resolution of weak and close transitions in lipid polymorphs, polymeric nanoparticles, and cellular membrane materials. Materials research at Mississippi State University (MSU) is limited by current thermal analysis equipment because: 1) existing DSCs do not have cooling to allow for operation at sub-ambient temperatures, 2) existing DSCs cannot operate in a modulated temperature mode and therefore cannot detect subtle phase transitions, 3) no STA is present and so simultaneous DCS and TGA of a sample cannot be performed, and 4) existing DSCs and TGAs are fully utilized. The requested MDSC/STA/TGA-IR suite will provide much needed capabilities to allow for innovative research, such as that proposed in lipid crystals and nanocrystals, thermally responsive nanoparticles, renewal polymers, and membrane chemistry.Intellectual Merit: Acquisition of these instruments will provide the infrastructure necessary to make substantial progress in three important fields of particulate materials research: crystallization, polymers, and biomembrane chemistry. While diverse, the PIs proposed work in each of these fields is based on materials characterization and requires access to research grade thermal analysis instrumentation. The PIs prior efforts have been significantly hampered by the lack of low or no cost access to adequate thermal analysis equipment. The MDSC, STA, and TGA-IR interface will allow for both new and expanded research. For lipids, thermal analysis will determine polymorphic form and the presence of hydrates or solvates, which will allow optimization of crystallization conditions; high resolution measurements will enable novel research in the area of solid lipid nanoparticles (NPs) as well as with nanostructured lipid carriers. Stimuli responsive polymers will be grafted from NPs using surface confined living radical polymerization techniques that allow for control over molecular weights and grafting densities. A series of thermally responsive core-shell NPs will be produced and the thermal analysis suite requested will allow for detection of weak and strong phase transitions, differentiation between volatile loss, thermal decomposition, and phase transitions, and evolved gas identification. For biological membrane research, thermal characterization will help assess antigen inclusion into liposomal membranes (model cells) for comparison with the physiologically relevant red blood cell system. Next, nanoparticle-conjugated ABO antigens in both the liposomes and red blood cells will be examined and will help determine the altered ABO antigens impact on red blood cell responses in dielectrophoretic microdevices.Broader Impacts: This instrumentation will improve the materials characterization infrastructure of the department, college, and university. These characterization tools will be utilized by the PIs in their course instruction. Long term outcomes include innovative particulates research and enhanced student education and training. The PIs are committed to actively recruiting undergraduate and graduate students from underrepresented groups to participate in their research activities. Education will be integrated with research via instrument usage in graduate student research, and by incorporating concepts and research data into four elective courses for engineering and science students. The instruments will provide students with access to cutting edge thermal characterization techniques; and the elective courses will provide concrete connections between theory and application, and interdisciplinary study. This enhanced training will provide a long term benefit to society via student contributions in their respective disciplines. Hill's lipid research has multiple applications in foods, personal care products, and pharmaceuticals. Walters research on thermally responsive NPs can lead to the development of new drug delivery methods, data storage technologies, and selective separations. Minerick's biomedical microdevice research has the potential to impact blood cell diagnostic microdevices and contributes to sustainability by decreasing resource utilization for chemical analysis. The equipment requested will transform research capabilities for each of the PIs research efforts at Mississippi State.

该设备提案的目的是获得一套热表征仪器，包括调制差示扫描量热计（MDSC），同时热分析仪（STA），包括DSC和热重分析（TGA），以及TGA- ir接口附件。这些仪器的综合功能将允许高灵敏度，高分辨率，复杂热事件的区分，以及脂质多晶型，聚合物纳米颗粒和细胞膜材料的弱和紧密转变的分辨率。密西西比州立大学（MSU）的材料研究受到当前热分析设备的限制，因为：1)现有的dsc没有冷却功能，无法在亚环境温度下工作；2)现有的dsc不能在调制温度模式下工作，因此无法检测到细微的相变；3)没有STA，因此无法同时对样品进行DCS和TGA分析；4)现有的dsc和TGAs被充分利用。所要求的MDSC/STA/TGA-IR套件将提供急需的能力，以允许创新研究，如脂质晶体和纳米晶体，热响应纳米颗粒，更新聚合物和膜化学。知识价值：获得这些仪器将提供必要的基础设施，以在颗粒材料研究的三个重要领域取得实质性进展：结晶，聚合物和生物膜化学。虽然不同，但这些领域的pi建议工作都是基于材料特性的，并且需要使用研究级热分析仪器。由于缺乏低成本或没有成本获得足够的热分析设备，pi先前的努力受到了严重阻碍。MDSC， STA和TGA-IR接口将允许新的和扩展的研究。对于脂类，热分析将确定多晶型和水合物或溶剂化物的存在，这将允许优化结晶条件；高分辨率测量将使固体脂质纳米颗粒（NPs）以及纳米结构脂质载体领域的新研究成为可能。刺激响应聚合物将使用表面受限活性自由基聚合技术从NPs接枝，该技术允许控制分子量和接枝密度。将生产一系列热响应核壳NPs，所要求的热分析套件将允许检测弱和强相变，区分挥发性损失，热分解和相变，以及演化气体识别。对于生物膜研究，热表征将有助于评估抗原在脂质体膜（模型细胞）中的包裹性，以便与生理学相关的红细胞系统进行比较。接下来，将对脂质体和红细胞中的纳米粒子偶联ABO抗原进行检查，并将有助于确定改变的ABO抗原对介电泳微设备中红细胞反应的影响。更广泛的影响：该仪器将改善系、学院和大学的材料表征基础设施。这些表征工具将被pi在他们的课程指导中使用。长期成果包括创新微粒研究和加强学生教育和培训。pi致力于从代表性不足的群体中积极招募本科生和研究生参加他们的研究活动。通过在研究生研究中使用仪器，以及将概念和研究数据纳入工程和科学学生的四门选修课程，教育将与研究相结合。这些仪器将为学生提供最前沿的热表征技术；选修课程将提供理论与应用之间的具体联系，以及跨学科的研究。这种加强的培训将通过学生在各自学科的贡献为社会带来长期利益。Hill的脂质研究在食品、个人护理产品和药品方面有多种应用。沃尔特斯对热响应NPs的研究可以导致新的药物递送方法，数据存储技术和选择性分离的发展。Minerick的生物医学微设备研究有可能影响血细胞诊断微设备，并通过减少化学分析的资源利用率来促进可持续性。所要求的设备将改变pi在密西西比州立大学的每个研究工作的研究能力。