Improving Performance Characteristics of Hyphenated Preconcentrator GC Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: A "Gold Standard" for Sensor Development

改进联用预浓缩器的性能特征 GC 傅里叶变换离子回旋共振质谱：传感器开发的“黄金标准”

• 批准号: 0228971
• 负责人: Touradj Solouki
• 金额: $ 9.95万
• 依托单位: University of Maine
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-10-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0228971&HistoricalAwards=false
• 关键词: Improving; Performance; Characteristics; Hyphenated; Preconcentrator

Professor Touradj Solouki of the University of Maine at Orono (UMO) is supported by the Analytical and Surface Chemistry Program to investigate cryofocusing of analytes in an Electrospray Ionization Fourier Transform Ion Cyclotron Resonance (ESI-FT-ICR) mass spectrometer. To overcome sensitivity problems of FT-ICR, Professor Solouki has added a pre-concentration (PC) gas chromatograph (GC) step to his setup. The goal of this Small Grant for Exploratory Research is to add an additional device: a cryofocuser after the GC. This is predicted to improve the detection limit by two orders of magnitude, and mass resolving power by a factor of 5-10. The PI will then identify biomarkers for sensor development and establish a "gold standard" to evaluate analytical performance of sensor devices. Undergraduate and graduate students participate in the research.Mass spectrometry is being developed as an almost "universal detector" and has been utilized to detect trace amounts of substances such as chemical and biological weapons. The instrument being developed in this research, while not fieldable as a sensor directly due to size and cost, can aid in the development of low cost, accurate sensors. It is thus of interest in national security, as well as a host of other medical and environmental applications.

缅因大学奥罗诺分校（UMO）的Touradj Solouki教授在分析和表面化学项目的支持下，研究了电喷雾电离傅立叶变换离子回旋共振（ESI-FT-ICR）质谱仪中分析物的低温聚焦。为了克服FT-ICR的灵敏度问题，Solouki教授在他的装置中增加了预浓缩（PC）气相色谱仪（GC）步骤。这项探索性研究小额拨款的目标是在GC之后增加一个额外的设备：低温聚焦器。预计这将使探测极限提高两个数量级，质量分辨能力提高5-10倍。然后，PI将确定传感器开发的生物标志物，并建立“金标准”来评估传感器设备的分析性能。本科生和研究生参与研究。质谱法正在发展成为一种几乎“通用的检测器”，并已被用于检测微量物质，如化学和生物武器。在这项研究中开发的仪器，虽然由于尺寸和成本的原因不能直接作为传感器，但可以帮助开发低成本，精确的传感器。因此，它对国家安全以及许多其他医疗和环境应用都有兴趣。