US-Germany Cooperative Research: Exchange of Viral Vector and Microdialysis Techniques for Studying Neuropeptide Function

美德合作研究：交换病毒载体和微透析技术研究神经肽功能

• 批准号: 0233145
• 负责人: Larry Young
• 金额: $ 1.23万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0233145&HistoricalAwards=false
• 关键词: US; Germany; Cooperative; Research; Exchange

0233145YoungThis award supports the PI and postdoctoral students from Emory University in a collaboration with Inga Neumann of the Institute for Zoology at the University of Regensburg, Germany. The combined efforts of the German and US groups will focus on their shared interest in the role of the neuropeptides oxytocin and vasopressin in the regulation of social behavior and stress coping. The US group at the NSF Center for Behavioral Neuroscience focuses on the role of oxytocin and vasopressin in social attachment of the monogamous rodent species the prairie vole. Studies suggest that oxytocin and vasopressin are released in the nucleus accumbens and ventral pallidum during mating, which trigger the pair bond formation. There is, however, no direct evidence of peptide release during mating in the monogamous voles. This issue will be addressed in the collaboration using in vivo microdialysis and sensitive radioimmunoassay. The German group is the only one in the world to have successfully measured oxytocin and vasopressin release in behaving rodents.The project also has an educational objective. The project will allow the postdoctoral students involved to benefit from performing research in another country. They will develop a heightened appreciation of the world around them while also learning important new technical skills.

0233145young该奖项支持PI和埃默里大学的博士后学生与德国雷根斯堡大学动物研究所的Inga Neumann合作。德国和美国研究小组的联合努力将集中在他们共同感兴趣的神经肽催产素和抗利尿激素在调节社会行为和应对压力方面的作用。美国国家科学基金会行为神经科学中心的研究小组专注于催产素和加压素在草原田鼠这种一夫一妻制啮齿动物的社会依恋中的作用。研究表明，在交配过程中，伏隔核和腹侧白球释放催产素和加压素，从而触发配对结合的形成。然而，在一夫一妻制田鼠的交配过程中，没有直接的证据表明肽释放。这个问题将在使用体内微透析和敏感放射免疫测定的合作中得到解决。这个德国研究小组是世界上唯一一个成功测量出行为正常的啮齿动物体内催产素和抗利尿激素释放量的研究小组。该项目还有一个教育目的。该项目将允许参与的博士后学生从在另一个国家进行研究中受益。他们将在学习重要的新技术技能的同时，提高对周围世界的欣赏。