Meristem Identity Genes and the Evolution of Plant Architecture in Brassicaceae
十字花科分生组织识别基因和植物结构的进化
基本信息
- 批准号:0234118
- 负责人:
- 金额:$ 34.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-02-01 至 2007-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
0234118BaumThe development of plants is controlled by meristems, areas of organized cell division and differentiation. Shoot meristems can take on either a floral or vegetative identity depending upon the activity of a set of meristem identity genes. Because flowers terminate shoot growth, the distribution of flowers, and hence the regulation of meristem identity genes, may have a profound affect upon plant architecture. Thus, it has been hypothesized that the architectural differences between species are largely driven by changes in meristem identity genes. In the proposed work we will evaluate the role of three meristem identity genes, LFY, TFL1, and AP1, in explaining why three species of the mustard/cabbage family (Brassicaceae) produce flowers from the basal rosette of leaves rather than on an elongated leafless stem (the inflorescence).In previous work the PI studied LFY genes from three rosette flowering species, Ionopsidium acaule (Ia), Idahoa scapigera (Is), and Leavenworthia crassa (Lc). They used transformation to introduce LFY genes from these three species into plants of an inflorescence flowering species, Arabidopsis thaliana (that lacked a functional endogenous copy of LFY). They found that whereas Ia-LFY had no affect on plant architecture, the IsLFY and LcLFY genes tended to induce modifications to plant architecture reminiscent of rosette flowering, but they did not cause complete conversion to rosette flowering. This result suggests that evolutionary changes at the LFY locus contributed to the parallel evolution of rosette flowering in these species, but point to additional, as yet unidentified, genetic changes. The proposed work will include follow-up experiments on LFY aimed at determining whether the important differences between species are located in the protein-coding region or the adjacent regulatory DNA. Similar experiments with AP1 and TFL1 will be done to see if they may have contributed to the evolution of rosette flowering. Specifically, the goal is to clarify the molecular evolution of the genes and move them from the rosette flowering species into A. thaliana to see if they can induce rosette-flowering individually or jointly with the exogenous LFY genes.This proposed study will shed light on how evolutionary changes in DNA translate into difference in the morphology of living species. In particular, the work will clarify: (1) the extent to which genetic changes are concentrated in a small set of developmental genes, (2) the relative importance of protein versus regulatory changes, and (3) the extent to which parallel evolution in independent lineages uses the same genetic toolbox. Additionally, the specific understanding of how plant architecture is regulated could ultimately have significance for efforts to modify crop plants to facilitate higher productivity and easier harvesting.The research will contribute to the training of one graduate student and one postdoctoral scientist.
[01:41 . 18]鲍姆植物的发育是由分生组织控制的,即有组织的细胞分裂和分化的区域。茎的分生组织可以采取花或营养的身份取决于一组分生组织身份基因的活动。由于花终止茎的生长,因此花的分布以及分生组织身份基因的调控可能对植物的结构产生深远的影响。因此,我们假设物种之间的结构差异很大程度上是由分生组织同源基因的变化驱动的。在这项工作中,我们将评估三个分生组织识别基因LFY, TFL1和AP1的作用,以解释为什么芥菜/卷心菜科(芸苔科)的三个物种从叶的基部莲座而不是在一个细长的无叶茎(花序)上开花。在之前的工作中,PI研究了三种莲座花物种的LFY基因,即Ionopsidium acaule (Ia),爱达荷州的scapigera (Is)和Leavenworthia crassa (Lc)。他们通过转化将这三个物种的LFY基因引入到花序开花物种拟南芥(缺乏LFY功能内源拷贝)的植物中。他们发现Ia-LFY对植物结构没有影响,而IsLFY和LcLFY基因倾向于诱导植物结构的修饰,使人联想到莲座花,但它们并没有完全转化为莲座花。这一结果表明,LFY位点的进化变化促进了这些物种的莲座花的平行进化,但指出了其他尚未确定的遗传变化。拟议的工作将包括对LFY的后续实验,旨在确定物种之间的重要差异是位于蛋白质编码区还是邻近的调控DNA。将对AP1和TFL1进行类似的实验,看看它们是否可能对莲座花的进化做出了贡献。具体来说,我们的目标是澄清这些基因的分子进化,并将它们从莲座开花物种转移到拟南芥中,看看它们是否能单独或与外源LFY基因共同诱导莲座开花。这项提议的研究将阐明DNA的进化变化如何转化为现存物种形态的差异。特别是,这项工作将澄清:(1)遗传变化集中在一小组发育基因中的程度,(2)蛋白质与调节变化的相对重要性,以及(3)独立谱系中的平行进化在多大程度上使用相同的遗传工具箱。此外,对植物结构如何调控的具体理解最终可能对改造作物植物以提高生产力和更容易收获的努力具有重要意义。该研究将有助于培养一名研究生和一名博士后科学家。
项目成果
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David Baum其他文献
137 EXTENDED USE OF PROSTAGLANDIN E1 (PgE1) IN NEONATES
前列腺素 E1(PGE1)在新生儿中的广泛应用 137
- DOI:
10.1203/00006450-198104001-00146 - 发表时间:
1981-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Andrew D Fryer;Paul T Pitlick;John D Couison;James W French;David Baum - 通讯作者:
David Baum
Insulin dependent diabetes in children under 5: incidence and ascertainment validation for 1992
5 岁以下儿童胰岛素依赖型糖尿病:1992 年的发病率和确定验证
- DOI:
- 发表时间:
1995 - 期刊:
- 影响因子:0
- 作者:
E. Wadsworth;Julian P H Shield;L. Hunt;David Baum - 通讯作者:
David Baum
Exploring the Design Space of Aesthetics with the Repertory Grid Technique
用Repertory Grid技术探索美学的设计空间
- DOI:
10.1007/978-3-030-68766-3_24 - 发表时间:
2020 - 期刊:
- 影响因子:0
- 作者:
David Baum - 通讯作者:
David Baum
Long-term survivors of pediatric heart transplantation: a multicenter report of sixty-eight children who have survived longer than five years.
儿科心脏移植的长期幸存者:一份针对 68 名存活超过五年的儿童的多中心报告。
- DOI:
10.1016/s0022-3476(97)70270-1 - 发表时间:
1997 - 期刊:
- 影响因子:0
- 作者:
G. Sigfússon;G. Sigfússon;F. Fricker;F. Fricker;Daniel Bernstein;Daniel Bernstein;L. Addonizio;L. Addonizio;David Baum;David Baum;Daphne T. Hsu;Daphne T. Hsu;Clifford Chin;Clifford Chin;Susan A. Miller;Susan A. Miller;Gerard J. Boyle;Gerard J. Boyle;Joan Miller;Joan Miller;K. Lawrence;K. Lawrence;Judith F. Douglas;Judith F. Douglas;B. Griffith;B. Griffith;Bruce A. Reitz;Bruce A. Reitz;Robert E. Michler;Robert E. Michler;Eric A. Rose;Eric A. Rose;Steve Webber;Steve Webber - 通讯作者:
Steve Webber
The upper limb-cardiovascular syndrome. An autosomal dominant genetic effect on embryogenesis.
上肢心血管综合征。
- DOI:
10.1001/jama.1965.03090130008002 - 发表时间:
1965 - 期刊:
- 影响因子:0
- 作者:
Kenneth B. Lewis;Robert A. Bruce;David Baum;Arno G. Motulsky - 通讯作者:
Arno G. Motulsky
David Baum的其他文献
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{{ truncateString('David Baum', 18)}}的其他基金
Collaborative Research: From ecological dynamics to adaptive evolution during the origin of life
合作研究:从生态动力学到生命起源期间的适应性进化
- 批准号:
2218817 - 财政年份:2022
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
EAGER Collaborative Proposal: A microfluidic platform for the discovery of new, life-like chemical systems
EAGER 合作提案:用于发现新的、逼真的化学系统的微流体平台
- 批准号:
1624562 - 财政年份:2016
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
Collaborative Research: Multilocus phylogenetics and species delimitation using sequence-capture and next-gen sequencing and its application in Adansonia (Malvaceae)
合作研究:使用序列捕获和下一代测序进行多位点系统发育和物种定界及其在 Adansonia(锦葵科)中的应用
- 批准号:
1354793 - 财政年份:2014
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
The molecular mechanisms by which genes alter development when moved between closely related species
当基因在密切相关的物种之间移动时改变发育的分子机制
- 批准号:
1021930 - 财政年份:2010
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
The Genetic Basis of Rosette Flowering in Leavenworthia
莱文沃斯莲座丛开花的遗传基础
- 批准号:
0641428 - 财政年份:2007
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
Dissertation Research: Systematics and Evolution of the Malagasy Endemic Genus Megistostegium (Malvaceae)
论文研究:马达加斯加特有属Megistostegium(锦葵科)的系统学和进化
- 批准号:
0608444 - 财政年份:2006
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
Dissertation Research: Systematics and Biogeography of the Pedilanthus Clade (Euphorbia-Euphorbiaceae)
论文研究:Pedilanthus Clade(大戟科)的系统学和生物地理学
- 批准号:
0608428 - 财政年份:2006
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
Phylogeny of Malvatheca (Malvaceae) and the Pace and Place of Its Evolution
锦葵科(锦葵科)的系统发育及其进化的速度和地点
- 批准号:
0416096 - 财政年份:2005
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
Symposium: Regulatory Genes and the Evolution of Plant Phenotype, June 2004
研讨会:调控基因和植物表型的进化,2004 年 6 月
- 批准号:
0353713 - 财政年份:2004
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
DISSERTATION RESEARCH: Pollinator-mediated Evolution and Diversification of Andean Solanaceae
论文研究:传粉媒介介导的安第斯茄科进化和多样化
- 批准号:
0309310 - 财政年份:2003
- 资助金额:
$ 34.5万 - 项目类别:
Standard Grant
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基础真双子叶唐松草花器官识别基因的功能进化:对育种和授粉系统转变的影响
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