US-Germany Cooperative Research: Nanoparticulate Detoxification Agents and Their Effects on Myocyte Biosensors

0234727杜兰探索性研究小额资助（SGER）奖支持了兰迪杜兰、安妮唐纳利、蒂莫西莫雷和一名来自佛罗里达大学的学生与德国美因茨马克斯普朗克聚合物研究所的沃尔夫冈诺尔、斯特凡席勒和克里斯蒂安蒂勒曼的合作。这两个小组将一起进行实验，以支持最终的药物解毒应用。实验将涉及工程核/壳纳米颗粒对体外培养在微电极阵列支架上的心肌细胞解毒的能力。纳米颗粒将用于降低心脏细胞中的药物浓度。该合作还将尝试形成包含药物活性离子通道本身的模型膜，因为它们对药物解毒系统进行电化学实验。这项合作建立了佛罗里达大学由美国国家科学基金会资助的工程研究中心和德国马克斯普朗克研究所之间的联系。这些实验有可能提供基于细胞的生物传感器解毒应用的第一个例子，并将促进涉及核/壳非颗粒研究的广泛相关研究。作为合作的一部分，佛罗里达大学的一名研究生将花六个月的时间在美因茨的实验室做研究。

0234727DuranThis Small Grants for Exploratory Research (SGER) award supports Randy Duran, Anne Donnelly, Timothy Morey, and a student from University of Florida in a collaboration with Wolfgang Knoll, Stefan Schiller, and Christiane Thielemann of the Max Planck Institute for Polymer Research in Mainz, Germany. Together, the two groups will perform experiments in support of eventual drug detoxification applications. The experiments will involve the ability of engineered core/shell nanoparticles to detoxify ex vivo cardiac myocyte cells cultured on microelectrode array supports. The nanoparticles will be used to reduce drug concentrations in cardiac cells. The collaboration will also attempt to form model membranes containing the drug-active ion channels themselves as they perform electrochemical experiments with drug detoxification systems. The collaboration establishes a connection between the NSF-funded Engineering Research Center at the University of Florida and the Max Planck Insititute in Germany. The experiments have the potential to provide the first example of detoxification applications with cell-based biosensors and will facilitate a broad range of related studies involving core/shell nonoparticle research. As part of the collaboration, a University of Florida graduate student will spend six months doing research in the lab in Mainz.