CAREER: New Stoichiometric and Catalytic Metal-Mediated Reactions

这一无机化学、生物无机化学和金属有机化学项目的职业奖项支持Paul Chirik教授和他在康奈尔大学化学和化学生物学系的研究小组在化学合成方面的研究和教育活动。这项研究的目标是开发过渡金属试剂，以在其他惰性分子中诱导反应。Chirik教授和他的同事们特别感兴趣的是了解如何操纵金属中心周围的环境来诱导元素氮、磷和脂肪族碳-碳键的反应。最终，这些研究可能允许从未得到充分利用的自然资源中建造新的药物和其他商品和特种化学品。与这项研究相关的教育活动旨在展示化学合成在现代社会中发挥的重要作用。这些概念将作为工程师化学入门课程的一部分，一年级学生的研究生课程的一部分，以及为当地儿童和成年人设计的社区项目中的一部分。这项研究致力于通过新的方法将元素氮(可以从空气中提取)和元素磷直接固定到有机分子中，这可能会导致更节能的工业过程。将开展教育活动，向高等教育和周围社区的学生展示化学合成在现代社会中发挥的重要作用。

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research and educational activities in chemical synthesis by Professor Paul Chirik and his research group in the Department of Chemistry and Chemical Biology at Cornell University. The goal of the research is to develop transition metal reagents to induce reactivity in otherwise inert molecules. Professor Chirik and coworkers are particularly interested in learning how the environment around the metal center can be manipulated to induce reactivity with elemental nitrogen, phosphorus and aliphatic carbon-carbon bonds. Ultimately, these studies may allow construction of new pharmaceuticals and other commodity and specialty chemicals from underutilized natural resources. Educational activities connected with this research are designed to demonstrate the vital role chemical synthesis plays in modern society. These concepts will be presented as part of an introductory chemistry course for engineers, a graduate course for first year students, as well as in community programs designed to reach children and adults in the local area.This research strives to fix elemental nitrogen, which can be derived from air, and elemental phosphorous, directly into organic molecules through new methods that could lead to more energy efficient industrial processes. Educational activities will be developed to demonstrate to students both in higher education and in the surrounding community the vital role that chemical synthesis plays in modern society.