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GOALI: An Industrial-Academic Collaboration for Sustainable Catalysis with Earth Abundant Metals

GOALI：利用地球丰富的金属进行可持续催化的产学合作

基本信息

批准号：
1855719
负责人：
Paul Chirik
金额：
$ 75万
依托单位：
Princeton University
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-01 至 2023-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1855719&HistoricalAwards=false
关键词：
GOALI Industrial Academic Collaboration Sustainable

项目摘要

The Catalysis Program of the Chemistry Division of the National Science Foundation supports the research of Professor Paul Chirik at Princeton University. This research project is conducted in collaboration with Drs. Rebecca Ruck and Danielle Schultz and at Merck & Co. Inc. The research team is designing new catalysts - complexes that speed up desirable chemical reactions, often used for making pharmaceutical drugs, agricultural products, and other specialty and commodity chemicals. This team is designing and developing new catalysts using "earth-abundant elements" such as iron and cobalt. These elements are cheaper and more abundant than silver, gold, platinum, and other metals that are often used in industrial catalysis. The challenge in this work is that many commercial processes are optimized for platinum metals. To design replacements for these expensive and rare metals, the team is studying the detailed steps in the chemical reactions. The research team is taking advantage of high throughput robotics and "ligand libraries" to test large numbers of new catalysts rapidly and safely. Due to the strong collaboration with industry, this project results in excellent work experience for the next generation of scientists. Coworkers on this project include those from historically underrepresented groups. Catalysis with first row transition metals, particularly iron and cobalt, as alternatives to precious metals is attractive. In addition to the potential cost and environmental benefits, these metals have often been shown to exhibit superior performance in terms of activity, selectivity, solvent profile as well as their unique abilities to produce new transformations. This research, conducted in collaboration with the chemical company Merck, focuses on understanding the mechanisms of first row transition metals in catalysis relevant to drug synthesis. Specific reactions of interest include methods for the stereoselective preparation of versatile polyboron compounds, asymmetric chain-running reactions to set remote stereocenters, and alcohol activation reactivity. Collaboration is key to this effort as fully integrated high throughout experiments, analytic methods, and target selection are facilitated by the industrial group, whereas fundamental organometallic chemistry, spectroscopy, and electronic structure determinations are done at Princeton. The broader impacts of the research takes advantage of the unique training environment created from the academic-industrial partnership to solve societal sustainability challenges. Educational efforts include elementary age children, non-scientist majors and advanced undergraduates and graduates studying catalysis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

国家科学基金会化学部的催化计划支持普林斯顿大学保罗·奇里克教授的研究。这项研究项目是与Rebecca Ruck和Danielle Schultz博士以及默克公司合作进行的。研究团队正在设计新的催化剂--能够加速理想的化学反应的络合物，通常用于制造药物、农产品和其他特种和日用化学品。该团队正在设计和开发使用铁和钴等“富含地球元素”的新型催化剂。这些元素比工业催化中经常使用的银、金、铂和其他金属更便宜、更丰富。这项工作的挑战是，许多商业流程都针对铂金属进行了优化。为了设计这些昂贵和稀有金属的替代品，该团队正在研究化学反应的详细步骤。研究团队正在利用高通量机器人技术和“配位库”快速、安全地测试大量新型催化剂。由于与业界的强大合作，该项目为下一代科学家带来了极好的工作经验。这个项目的同事包括那些来自历史上代表性不足的群体的人。用第一排过渡金属，特别是铁和钴作为贵金属的替代品进行催化是有吸引力的。除了潜在的成本和环境效益外，这些金属经常被证明在活性、选择性、溶剂分布以及产生新转化的独特能力方面表现出优异的性能。这项研究是与默克化学公司合作进行的，重点是了解第一排过渡金属在与药物合成相关的催化中的作用机理。感兴趣的具体反应包括多用途多硼化合物的立体选择性制备方法，设置远程立体中心的不对称链式反应，以及酒精活化反应性。协作是这项工作的关键，因为在整个实验、分析方法和目标选择过程中，完全集成的实验、分析方法和目标选择都是由工业组促进的，而基础金属有机化学、光谱学和电子结构确定是在普林斯顿完成的。这项研究的更广泛影响是利用学术-产业伙伴关系创造的独特培训环境来解决社会可持续发展挑战。该奖项反映了NSF的法定使命，通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。