Murid Rodent Phylogenetics Using Multiple Nuclear Genes

使用多个核基因进行鼠类啮齿动物系统发育

• 批准号: 0238837
• 负责人: Ronald Adkins
• 金额: $ 10万
• 依托单位: The University of Tennessee, Memphis - The Health Science Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-10-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0238837&HistoricalAwards=false
• 关键词: Murid; Rodent; Phylogenetics; Using; Multiple

A grant has been awarded to Dr. Ronald Adkins at the University of Tennessee to work in collaboration with Dr. Scott Steppan of Florida State University to study the evolutionary relationships of the largest family of mammals (Muridae) which includes the common mouse and rat. Although Muridae includes one fourth of all mammals and has immense importance to agriculture, disease, and biomedical research, the relationships among these species distributed throughout the world are extremely unclear. Drs. Adkins and Steppan are sequencing DNA from several genes from a large number of species in this group. Based on computer analysis of the patterns of mutation among the species, the evolutionary tree of Muridae will be reconstructed. The laboratory mouse and rat are the premier research models for human disease and will soon have their entire genomes sequenced. Additionally, serious diseases, such as plague and hantavirus, are spread by parasites harbored by some members of Muridae. Rats, mice and their relatives are also major agricultural consumers and under certain conditions can account for over half of the plant material eaten by herbivores. Significantly, the worldwide distribution of Muridae grants them a unique role in understanding the climatological, geological, and ecological changes that have shaped the world. Having the evolutionary tree of these species will clarify the large-scale genomic changes that distinguish rodents from other mammals (including humans) and will greatly facilitate our understanding of their roles as biomedical models, disease vectors, engines of ecological change, and will allow us to reconstruct the history of this group in the context of ancient geological and climatological events.

田纳西大学的罗纳德阿德金斯博士获得了一笔赠款，与佛罗里达州立大学的斯科特斯特潘博士合作研究哺乳动物中最大的家族（鼠科）的进化关系，其中包括常见的老鼠和老鼠。 尽管鼠科包括所有哺乳动物的四分之一，并且对农业，疾病和生物医学研究具有巨大的重要性，但分布在世界各地的这些物种之间的关系非常不清楚。 阿德金斯和斯特潘博士正在对这一群体中大量物种的几个基因进行DNA测序。 在计算机分析鼠科物种间突变模式的基础上，重建鼠科的进化树。实验室小鼠和大鼠是人类疾病的首要研究模型，不久将对它们的整个基因组进行测序。 此外，鼠疫和汉坦病毒等严重疾病也是由鼠科某些成员携带的寄生虫传播的。 大鼠、小鼠及其亲属也是主要的农业消费者，在某些条件下，它们可以占食草动物所食用植物材料的一半以上。 值得注意的是，鼠科的全球分布赠款它们在理解塑造世界的气候，地质和生态变化方面发挥了独特的作用。 拥有这些物种的进化树将澄清啮齿动物与其他哺乳动物（包括人类）的大规模基因组变化，并将大大促进我们对它们作为生物医学模型，疾病载体，生态变化引擎的角色的理解，并将使我们能够在古代地质和气候事件的背景下重建这一群体的历史。