The capacity for exceptional brain repair in a novel rodent species.

一种新型啮齿动物具有特殊的大脑修复能力。

• 批准号: DP240102825
• 负责人: Prof Mary Tolcos
• 金额: $ 37.11万
• 依托单位: RMIT University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-01-01 至 2026-12-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240102825
• 关键词: capacity; exceptional; brain; repair; novel

This project aims to provide a new and much-needed living tool for studying brain injury and repair. The project expects to generate new evidence of effective brain repair in a mammalian species, the spiny mouse. In particular, it will provide important knowledge of the cellular responses that coordinate to allow mammalian brain repair, revealing targets for future understanding and treatment. Expected outcomes include an in-depth characterisation of how neurons and non-neuronal cells (glia) contribute to brain repair, and the identification of new pathways or targets for mammalian brain repair. In the long-term this should provide significant benefits for future research focused on improving the lives of people affected by brain injury.

该项目旨在为研究脑损伤及其修复提供一种新的急需的活体工具。该项目希望在哺乳动物——多刺鼠——身上找到有效修复大脑的新证据。特别是，它将提供有关协调哺乳动物大脑修复的细胞反应的重要知识，揭示未来理解和治疗的目标。预期结果包括神经元和非神经元细胞（胶质细胞）如何促进大脑修复的深入表征，以及确定哺乳动物大脑修复的新途径或靶点。从长远来看，这将为未来专注于改善脑损伤患者生活的研究提供重大好处。