PECASE: Harnessing Electrokinetic Flow Instabilities for Next Generation Microfluidics

PECASE：利用动电流动不稳定性实现下一代微流体

• 批准号: 0239080
• 负责人: Juan Santiago
• 金额: $ 40万
• 依托单位: Stanford University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-15 至 2008-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239080&HistoricalAwards=false
• 关键词: PECASE; Harnessing; Electrokinetic; Flow; Instabilities

Proposal Title: PECASE: Harnessing Electrokinetic Flow Instabilities for NextGeneration MicrofluidicsInstitution: Stanford UniversityAmong the greatest engineering challenges of the century are the development of technologies that will enable massively parallel drug discovery efforts, biomedical device design, fundamental genetics research, proteomics, and rapid and miniaturized biological weapon detection. On-chip microfluidics has an important and expanding role in the realization of such tools and offers the potential of massively parallel chemical laboratories on a chip. Electrokinetic (EK) devices, in particular, combine "work-horse" processes such aselectrophoresis, binding assays, and electro-chromatography with a precise control of sample streams in compact, easy-to-fabricate devices with no moving parts. Recent experiments performed in the Stanford Microfluidics Laboratory demonstrate that there is an important class of EK flows that are not well understood and largely undocumented: EK flow instabilities that arise in heterogeneous property liquid streams. These instabilities occur in a variety of geometries relevant to on-chip assays, and flows with ionic conductivity gradients are particularly susceptible. The research plan is integrated closely with undergraduate and graduate teaching and the recruitment and retention of students of underrepresented groups in engineering at the high school, undergraduate, and graduate level. NSF funding will enable several key efforts. First is a significant expansion of an ongoing effort to convert teaching material from three engineering classes into a multimedia format that leverages screen-projected and animated notes as well as digitized movie clips for effective lecturing. Funding will also be used to expand the student base of a newly-developed course on Fluid Flow in Microdevices by making the course available to other institutions (including industry and government labs) via the Stanford Instructional Television Network. Third, NSF funds will be used to recruit students of underrepresented groups by leveraging a collaboration with the Foundation for a College Education (FCE) to conduct a series of workshops to advise high school students on planning for college, completing college applications (e.g., help with college essays), and introducing them to the many rewards of careers in science and engineering. At the undergraduate level, NSF funding will be used to increase student involvement in research by expanding a collaboration with Stanford's Office of Engineering Diversity Programs. At the graduate level, the award will help the applicant expand his role in actively mentoring and motivating graduate students fromunderrepresented groups in the developing field of microfluidics research.This project was originally funded as a CAREER award, and was converted to a Presidential Early Career Award for Engineers and Scientists (PECASE) award in September 2004.

提案标题：PECASE：利用电动力学流动不稳定性的下一代微流体机构：斯坦福大学世纪最大的工程挑战之一是技术的发展，将使大规模并行药物发现工作，生物医学设备设计，基础遗传学研究，蛋白质组学，和快速和小型化的生物武器检测。芯片上微流体在实现这些工具方面具有重要和不断扩大的作用，并提供了芯片上大规模并行化学实验室的潜力。特别是电动（EK）设备，联合收割机将电泳、结合分析和电色谱等“主力”过程与样品流的精确控制结合在一起，设备紧凑、易于制造，没有移动部件。最近在斯坦福大学微流体实验室进行的实验表明，有一类重要的EK流，没有很好地理解和基本上没有记录：EK流不稳定性，出现在异质性液体流。这些不稳定性发生在与芯片上测定相关的各种几何形状中，并且具有离子电导率梯度的流动特别敏感。该研究计划与本科和研究生教学以及高中，本科和研究生阶段工程中代表性不足群体的学生的招聘和保留紧密结合。NSF的资助将使几个关键的努力。首先是一个正在进行的努力，从三个工程类转换成多媒体格式，利用屏幕投影和动画笔记以及数字化的电影剪辑有效的演讲教材的显着扩展。资金还将用于扩大一个新开发的课程的学生基础上流体流动的微器件，使课程提供给其他机构（包括行业和政府实验室）通过斯坦福大学教学电视网络。第三，NSF的资金将用于招募代表性不足群体的学生，利用与大学教育基金会（FCE）的合作，举办一系列研讨会，为高中生提供大学规划，完成大学申请（例如，帮助写大学论文），并向他们介绍科学和工程职业的许多回报。在本科阶段，NSF的资金将用于扩大与斯坦福大学工程多样性项目办公室的合作，以增加学生对研究的参与。在研究生阶段，该奖项将帮助申请人扩大他在积极指导和激励研究生方面的作用，这些研究生来自发展中的微流体研究领域的代表性不足的群体。该项目最初是作为一个职业奖资助的，并于2004年9月转换为工程师和科学家总统早期职业奖（PECASE）。