Improvements in Drift Tube Reaction Mass Spectrometry

漂移管反应质谱的改进

• 批准号: 0242922
• 负责人: Walter Knighton
• 金额: --
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0242922&HistoricalAwards=false
• 关键词: Improvements; Drift; Tube; Reaction; Mass

Professors Eric P. Grimsrud and Walter B. Knighton are funded by the Analytical and Surface Chemistry program for work on drift tube reaction mass spectrometry. The PI's seek to improve the performance of mass spectrometry for rapid trace measurement of volatile components in the atmosphere. An effective strategy for creating ions of trace components without saturating the mass spectrometer with an oxygen or nitrogen gas signal is ionization with the hydronium cation in a flow or drift tube before the mass spectrometer. In this proton transfer gas phase reaction, most trace components can be selectively and quantitatively ionized. However, the hydronium cation ion source is not without problems, principally water cluster formation and excessive fragmentation of the trace component. For these reasons, additional work is proposed on interrelated instrument parameters of drift tube pressure, flow velocity, and pressure as well as reaction rate studies for proton transfer from the hydronium ion to various trace components. Drift tube reaction mass spectrometry is a general technique by which the volatile organic compounds present in ambient air or human breath can be directly determined in real time without the time lag associated with more conventional methods of analysis. Improved methods such as these are needed for applications ranging from medicine to national security.

教授埃里克P格里姆斯鲁德和沃尔特B。Edghton由分析和表面化学计划资助，用于漂移管反应质谱法的工作。 PI的目的是提高质谱仪的性能，以快速跟踪测量大气中的挥发性成分。 在不使质谱仪被氧气或氮气信号饱和的情况下产生痕量组分的离子的有效策略是在质谱仪之前的流动管或漂移管中用水合氢阳离子电离。 在这种质子转移气相反应中，大多数痕量组分可以被选择性地和定量地电离。 然而，水合氢阳离子离子源并非没有问题，主要是水簇形成和痕量组分的过度碎裂。 出于这些原因，提出了额外的工作相关的仪器参数的漂移管的压力，流速和压力，以及反应速率的研究质子转移的水合氢离子的各种微量成分。漂移管反应质谱法是一种通用技术，通过该技术，可以直接在真实的时间内测定环境空气或人呼吸中存在的挥发性有机化合物，而没有与更常规的分析方法相关的时滞。 从医学到国家安全，都需要改进这些方法。