US-Turkey Cooperative Research: Development of Catalytic Asymmetric Azomethine Ylide Cycloaddition Reactions

该奖项支持俄亥俄州克利夫兰凯斯西储大学化学系Philip Garner博士和土耳其安卡拉中东技术大学化学系Ozdemir Dogan博士的合作研究项目。这个联合项目的目的是开发一种有效的催化不对称反应来合成纯吡咯烷。高纯度取代吡咯烷的制备方法的发展将是一项重大成就，因为吡咯烷亚结构存在于许多具有生物活性的天然产物和合成药物结构中。范围：部分催化剂开发工作将由多根集团的土耳其研究生Hasan Koyuncu在美国进行。他每年将在加纳实验室呆三个月，他的工作将成为他博士论文的一部分，加纳教授将担任Koyuncu先生的联合导师。国外的经历将有助于他的专业发展。多根和加纳对彼此实验室的访问将用于与项目有关的小组讨论和部门研讨会。这些活动将促进METU和CWRU之间日益增长的研究互动。该项目由国际科学与工程办公室和化学部资助。

0242964 GarnerDescription: This award supports a cooperative research project between Dr. Philip Garner, Department of Chemistry, Case Western Reserve University (CWRU), Cleveland, Ohio, and Dr. Ozdemir Dogan, Department of Chemistry, Middle East Technical University (METU), Ankara, Turkey. The objective of this joint project is to develop an effective catalytic asymmetric reaction for the synthesis of pure pyrrolidines. The development of means of preparation of substituted pyrrolidines in high purity would be a major achievement, as the pyrrolidine substructures are found in many bioactive natural products and synthetic drug structures. Scope: Part of the catalyst development work will be conducted in the U.S. by Hasan Koyuncu, who is a Turkish graduate student in the Dogan group. He will spend three months each year in the Garner laboratory, and his work will be part of his Ph.D. thesis with Professor Garner acting as Mr. Koyuncu's co-advisor. This experience abroad will contribute to his professional development. The visits by Dogan and Garner to each other's laboratories will be used for group discussions relating to the project, and for departmental seminars. These activities will foster the growing research interactions between METU and CWRU. The project is funded by the Office of International Science and Engineering and the Division of Chemistry.