US-Turkey Cooperative Research: Development of Catalytic Asymmetric Azomethine Ylide Cycloaddition Reactions

0242964 Garner描述：该奖项支持俄亥俄州凯斯西储大学（CWRU）化学系Philip Garner博士和土耳其安卡拉中东技术大学（METU）化学系Ozdemir Dogan博士之间的合作研究项目。 本项目的目标是开发一种有效的催化不对称反应合成纯吡咯烷。 由于吡咯烷亚结构存在于许多具有生物活性的天然产物和合成药物结构中，因此开发制备高纯度取代吡咯烷的方法将是一项重大成就。 范围：部分催化剂开发工作将在美国由Hasan Koyuncu进行，他是Dogan集团的土耳其研究生。 他每年将在加纳实验室工作三个月，他的工作将成为他博士学位的一部分。加纳教授担任科云库先生的共同顾问。 这段海外经历将有助于他的专业发展。 Dogan和Garner对彼此实验室的访问将用于与该项目有关的小组讨论和部门研讨会。这些活动将促进METU和CWRU之间日益增长的研究互动。 该项目由国际科学与工程办公室和化学司资助。

0242964 GarnerDescription: This award supports a cooperative research project between Dr. Philip Garner, Department of Chemistry, Case Western Reserve University (CWRU), Cleveland, Ohio, and Dr. Ozdemir Dogan, Department of Chemistry, Middle East Technical University (METU), Ankara, Turkey. The objective of this joint project is to develop an effective catalytic asymmetric reaction for the synthesis of pure pyrrolidines. The development of means of preparation of substituted pyrrolidines in high purity would be a major achievement, as the pyrrolidine substructures are found in many bioactive natural products and synthetic drug structures. Scope: Part of the catalyst development work will be conducted in the U.S. by Hasan Koyuncu, who is a Turkish graduate student in the Dogan group. He will spend three months each year in the Garner laboratory, and his work will be part of his Ph.D. thesis with Professor Garner acting as Mr. Koyuncu's co-advisor. This experience abroad will contribute to his professional development. The visits by Dogan and Garner to each other's laboratories will be used for group discussions relating to the project, and for departmental seminars. These activities will foster the growing research interactions between METU and CWRU. The project is funded by the Office of International Science and Engineering and the Division of Chemistry.