US-Turkey Cooperative Research Project: Studies on the Folding Dynamics of Proteins

美国-土耳其合作研究项目：蛋白质折叠动力学研究

• 批准号: 0352868
• 负责人: Ahmet Palazoglu
• 金额: --
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0352868&HistoricalAwards=false
• 关键词: US; Turkey; Cooperative; Research; Project

0352868 PalazogluDescription: This project supports a partnership between the Dr. Ahmet Palazoglu, Department of Chemical Engineering and Material Science, The University of California, Davis, California and a team of Turkish scientists including Dr. Attila Gursoy, Department of Computer Engineering, Koc University, Istanbul, Turkey and Dr. Burak Erman and Dr. Yaman Arkun, both of the Department of Chemical and Biological Engineering at Koc University. The focus of the research is the study of protein folding dynamics, with the emphasis on developing fast simulation platforms that can reliably predict the mechanisms of folding and analyzing the simulated trajectories to understand the fundamental features of how the protein folds to its native state. For simulating the folding dynamics, they plan to use coarse-grained fast-folding algorithms. Specifically, a coarse-grained Go-type model will be utilized. They will explore new directions, based on optimal control theory, in steering the protein to its known native state. Furthermore, they plan to use the principal components analysis (PCA) to characterize the large number of trajectories obtained by the fast-folding Go-type model, and perform wavelet decomposition to provide a multi-resolution analysis of their spatial and temporal features. The coarse-grained Go model will also be complemented by more extensive simulations of rigorous molecular dynamics (MD) for proteins in water and different accuracy levels will be probed.Scope: The proposed research on protein folding dynamics is a field of intense study in structural biology. The PI's expect the results of this research to have significant repercussions in understanding the fundamental mechanisms involved during the evolution of the protein from its denatured state to its native state. The two teams have complementary expertise in the related elements of the proposed work, and there is already a brief history of collaborative work between the two groups. The project will involve a junior researcher from Turkey as the lead PI and graduate students from both institutions. The travel between the U.S. and Turkey by the research teams will be organized in such a way as to provide ample time for interaction and substantial research during the year. The proposed research will help train graduate students and provide a synergistic environment in which they can appreciate the benefits of multi-disciplinary research. The results will be disseminated through scientific literature and will also be available on the Web pages of the leading PIs. The proposed activity will enhance our understanding of how proteins function and will have a direct impact on the well being of the society at large.

描述：该项目支持加州大学戴维斯分校化学工程与材料科学系Ahmet Palazoglu博士与土耳其科学家团队（包括土耳其伊斯坦布尔Koc大学计算机工程系Attila Gursoy博士和Koc大学化学与生物工程系Burak Erman博士和Yaman Arkun博士）之间的合作关系。研究重点是蛋白质折叠动力学的研究，重点是开发能够可靠预测折叠机制的快速仿真平台，并分析模拟轨迹，以了解蛋白质如何折叠到其原始状态的基本特征。为了模拟折叠动力学，他们计划使用粗粒度的快速折叠算法。具体来说，将使用粗粒度go类型模型。他们将在最优控制理论的基础上探索新的方向，将蛋白质引导到已知的天然状态。此外，他们计划使用主成分分析（PCA）来表征快速折叠go型模型获得的大量轨迹，并执行小波分解以提供其空间和时间特征的多分辨率分析。粗粒度Go模型还将通过对水中蛋白质的严格分子动力学（MD）进行更广泛的模拟来补充，并探索不同的精度水平。研究范围：蛋白质折叠动力学是结构生物学研究的热点领域。PI希望这项研究的结果对理解蛋白质从变性状态到天然状态的进化过程中涉及的基本机制产生重大影响。这两个团队在拟议工作的相关要素方面具有互补的专门知识，并且两个团队之间已经有了一段简短的合作历史。该项目将涉及来自土耳其的一名初级研究员作为首席PI和来自两个机构的研究生。研究小组在美国和土耳其之间的旅行将以这样一种方式组织，以便在一年中提供充足的时间进行互动和实质性的研究。拟议的研究将有助于培养研究生，并提供一个协同的环境，使他们能够体会到多学科研究的好处。研究结果将通过科学文献进行传播，并将在主要的项目评价机构的网页上提供。拟议的活动将增强我们对蛋白质功能的理解，并将对整个社会的福祉产生直接影响。