Microsolvation of individual DNA bases

单个 DNA 碱基的微溶剂化

• 批准号: 0244341
• 负责人: Mattanjah de Vries
• 金额: $ 45万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0244341&HistoricalAwards=false
• 关键词: Microsolvation; individual; DNA; bases

In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, the PI will conduct research on the properties and behaviors of individual nucleobases, nucleosides and nucleotides, with controlled numbers of water molecules. Experiments will be done by laser spectroscopy of water clusters, formed with laser desorbed, jet cooled bases. Molecular dynamics simulations and state-of-the-art nonempirical chemical ab initio calculations will complement the experimental work. Graduate and undergraduate students as well as postdoctoral associates will participate in the research. In addition, an outreach program is focused on minority students and high schools, and the development of a web based interface to facilitate access to science museum resources by grade school science teachers.

该项目由化学学部实验物理化学项目资助，PI将在控制水分子数量的情况下，对单个核碱基、核苷和核苷酸的性质和行为进行研究。实验将通过激光光谱对由激光解吸、射流冷却的碱基形成的水团簇进行分析。分子动力学模拟和最先进的非经验化学从头计算将补充实验工作。研究生和本科生以及博士后将参与研究。此外，还针对少数民族学生和高中开展了外展计划，并开发了一个基于网络的界面，以方便小学科学教师访问科学博物馆资源。