Microsolvation of individual DNA bases

单个 DNA 碱基的微溶剂化

• 批准号: 0244341
• 负责人: Mattanjah de Vries
• 金额: $ 45万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-15 至 2006-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0244341&HistoricalAwards=false
• 关键词: Microsolvation; individual; DNA; bases

In this project, funded by the Experimental Physical Chemistry Program of the Chemistry Division, the PI will conduct research on the properties and behaviors of individual nucleobases, nucleosides and nucleotides, with controlled numbers of water molecules. Experiments will be done by laser spectroscopy of water clusters, formed with laser desorbed, jet cooled bases. Molecular dynamics simulations and state-of-the-art nonempirical chemical ab initio calculations will complement the experimental work. Graduate and undergraduate students as well as postdoctoral associates will participate in the research. In addition, an outreach program is focused on minority students and high schools, and the development of a web based interface to facilitate access to science museum resources by grade school science teachers.

在这个项目中，由化学分裂的实验物理化学计划资助，PI将对具有控制的水分子数量的单个核苷酸酶，核苷和核苷酸的特性和行为进行研究。 实验将通过用激光解吸，喷射冷却碱的激光簇的激光光谱进行。 分子动力学模拟和最先进的非经验化学学位计算将补充实验工作。 研究生和本科生以及博士后同事将参加这项研究。 此外，外展计划的重点是少数族裔学生和高中，以及开发基于Web的界面，以促进小学科学教师访问科学博物馆资源。