The role of the conserved Schizosaccharomyces pombe 1/3 inositol polyphosphate kinase Asp1 in polarized growth

保守的粟酒裂殖酵母 1/3 肌醇多磷酸激酶 Asp1 在极化生长中的作用

• 批准号: 162065794
• 负责人: Professorin Dr. Ursula-Nicole Fleig
• 金额: --
• 依托单位: Institut für Funktionelle Genomforschung der Mikroorganismen
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/162065794?language=en
• 关键词: role; conserved; Schizosaccharomyces; pombe; inositol

Core mechanisms that regulate the polarity of a cell and its shape are evolutionarily conserved. Polarized cell growth, which determines cell shape, depends on a localized crosstalk between the microtubule and actin cytoskeletons and the cell membrane. Our work shows that the actin and microtubule regulator Asp1, an evolutionarily conserved Vip1 family IP6 kinase, links the actin and microtubule cytoskeletons and is essential for proper polarized growth in the fission yeast Schizosaccharomyces pombe. In addition, we have recently identified Asp1 as a molecular switch for the transition from a yeast form to cells that show invasive, hyphal-like growth. This is the first time that such a role has been described for a member of the Vip1 kinase family. The aim of this project is to understand how Asp1 and Asp1 interacting proteins regulate the switch from the yeast- to the hyphal-like invasive form.

调节细胞极性及其形状的核心机制在进化上是保守的。决定细胞形状的极化细胞生长依赖于微管和肌动蛋白细胞骨架与细胞膜之间的局部串扰。我们的工作表明，肌动蛋白和微管调节器Asp1，一个进化上保守的Vip1家族IP6激酶，连接肌动蛋白和微管细胞骨架，并在裂殖酵母裂殖酵母的适当极化生长是必不可少的。此外，我们最近已经确定Asp1作为从酵母形式过渡到显示侵入性菌丝样生长的细胞的分子开关。这是第一次描述Vip1激酶家族成员的这种作用。该项目的目的是了解Asp1和Asp1相互作用蛋白如何调节从酵母到菌丝样侵入形式的转换。