New Ligands and Catalysts for Asymmetric Synthesis

本研究的重点是手性双环内酰胺及其衍生物衍生的亲核和路易斯酸金属配合物的合成。这些配合物将在金属介导的功能化烯丙基部分对醛的加成、铜介导的共轭加成和[3,3]异位重排中进行评价。通过这个奖项，有机和大分子化学项目支持罗切斯特大学化学系Robert K. Boeckman博士的研究。Boeckman教授将致力于发展催化不对称合成的方法。这项工作有可能对制药业产生更广泛的影响，该项目将培养研究生成为有机合成方面的专家。

The focus of this research involves the synthetic use of nucleophilic and Lewis acid metal complexes derived from chiral bicyclic lactams and related derivatives. The complexes will be evaluated in the metal-mediated additions of functionalized allyl moieties to aldehydes, cuprate mediated conjugate additions and [3,3] sigmatropic rearrangements. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Robert K. Boeckman in the Department of Chemistry at the University of Rochester. Professor Boeckman will focus his research efforts on developing methodology for catalytic asymmetric synthesis. There is potential for broader impact of the work for the pharmaceutical industry and the project will train graduate students to become experts in organic synthesis.