CAREER: New Group VI Catalysts for Nitrile-Alkyne Cross Metathesis (NACM): Design, synthesis, and application of trianionic pincer ligands

该职业奖由无机、生物无机和有机金属化学项目颁发，支持佛罗里达大学 Adam S. Veige 教授的工作，即使用新型硬-硬-硬三阴离子钳配体开发用于腈-炔交叉复分解 (NACM) 反应的催化剂。 这些配体旨在稳定高氧化态的早期过渡金属。 尚未探索的 NACM 催化反应将检查钳配体对 M-N 多重键的反式影响，特别是在化学计量和催化交换反应中。 这项研究将带来削弱 M-N 键的新方法，这些键通常太稳定，以致 NACM 无法有效发挥作用。 炔/腈络合物的合成作为定向有机合成的工具可能具有广泛的适用性，因为催化剂可以为化学和制药工业提供更环保的合成方法。 除了培训本科生和研究生的研究技术外，维吉教授还希望通过“商场化学日”外展活动激发广大受众对研究的兴趣。 这些活动将鼓励科学家将接触公众视为其职业生涯的预期组成部分，同时鼓励年轻学生考虑科学职业。

This CAREER award by the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports the work of Professor Adam S. Veige at the University of Florida to develop catalysts for Nitrile-Alkyne Cross Metathesis (NACM) reactions using a new class of hard-hard-hard, trianionic pincer ligands. These ligands are designed to stabilize high oxidation state, early transition metals. The under-explored NACM catalysis reactions will examine the trans-influence of the pincer ligands on M-N multiple bonds, particularly in stoichiometric and catalytic exchange reactions. This research will lead to new methods for weakening M-N bonds, which are often too stable for NACM to work efficiently. The synthesis of alkyne/nitrile complexes may have broad applicability as a tool in directed organic synthesis as the catalysts could find offer more environmentally-friendly methods of synthesis for both the chemical and pharmaceutical industries. In addition to training undergraduate and graduate students in research techniques, the Professor Veige hopes to inspire wide audiences to develop an interest in research through "Chemistry Day at the Mall" outreach activities. These activities will encourage scientists to see outreach to the public as an expected part of their professional career while encouraging younger students to consider scientific careers.