Acquisition of a Liquid Chromatograph/Mass Spectrometer

购买液相色谱仪/质谱仪

• 批准号: 0946653
• 负责人: Robert Boeckman, Jr.
• 金额: $ 28.98万
• 依托单位: University of Rochester
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0946653&HistoricalAwards=false
• 关键词: Acquisition; Liquid; Chromatograph; Mass; Spectrometer

With this award from the Chemistry Research Instrumentation and Facilities: Departmental Multi-User Instrumentation program (CRIF:MU), Professor Robert K. Boeckman Jr. and Joseph P. Dinnocenzo of the University of Rochester will acquire a high sensitivity, ion trap mass spectrometer equipped with a modern liquid chromatograph (LC-MS), as well as electrospray (ES) and atmospheric pressure chemical ionization (APCI) ion sources. It will be employed in a variety of research projects including the study of: a) the chemistry of group 14 cation radical intermediates; b) the design and development of novel chemo-enzymatic and chemo-biosynthetic methods; c) the chemistry and properties of complexes of the heavier platinum and coinage group elements; d) the discovery of new reactions for the synthesis of natural products; e) the properties of unsaturated, reactive complexes of iron that are catalytically active; and, f) the activation of C-H, C-S, C-CN, and C-F bonds using isotopically labeled transition metal complexes.Mass spectrometry (MS) is used to identify the chemical composition of a sample and determine its purity by measuring the mass of the molecular constituents in the sample after they are ionized and detected by the mass spectrometer. Chromatography is an isolation technique that precedes the mass spectrometry analysis. It separates a mixture into its several constituent chemicals which are then analyzed by the mass spectrometer. These are widely used analytical techniques to identify and quantify the chemical composition of a sample. The acquisition will benefit undergraduate and graduate students through research programs in the Department and through utilization of the mass spectrometer in the undergraduate chemistry laboratories.

凭借化学研究仪器和设施：部门多用户仪器计划 (CRIF:MU) 的这一奖项，罗切斯特大学的 Robert K. Boeckman Jr. 教授和 Joseph P. Dinnocenzo 教授将获得一台配备现代液相色谱仪 (LC-MS) 以及电喷雾 (ES) 和大气压化学电离 (APCI) 的高灵敏度离子阱质谱仪 离子源。 它将用于各种研究项目，包括研究： a) 第 14 族阳离子自由基中间体的化学； b) 新型化学酶法和化学生物合成方法的设计和开发； c) 较重的铂族和造币族元素的络合物的化学和性质； d) 发现合成天然产物的新反应； e) 具有催化活性的不饱和反应性铁络合物的性质； f) 使用同位素标记的过渡金属配合物激活 C-H、C-S、C-CN 和 C-F 键。质谱 (MS) 用于鉴定样品的化学成分，并通过测量样品中分子成分电离并由质谱仪检测后的质量来确定样品的纯度。 色谱法是一种先于质谱分析的分离技术。它将混合物分离成几种化学成分，然后由质谱仪进行分析。这些是广泛使用的分析技术，用于识别和量化样品的化学成分。此次收购将使本科生和研究生受益于该系的研究项目以及本科生化学实验室中质谱仪的使用。