Supramolecular and Electrochemical Studies of Organometallics

德怀特·斯威加特，布朗大学，由无机，生物无机和有机金属化学项目支持，合成和研究由金属和有机金属分子自组装产生的超分子配位网络。该网络将基于过渡金属如锰、铁和钌的pi键醌配合物。这些网络具有电化学活性，具有广泛的可访问设计和架构。最初的目标包括合成包含大孔、纳米管和交叉指状pi-pi网络的材料。该项目还包括醌类化合物的稳定和研究，醌类化合物是一种高活性分子，在黑色素和木质素的生物合成、抗肿瘤药物的作用以及BHT等食品添加剂的代谢氧化等方面具有重要意义。醌类化合物的稳定性将通过与过渡金属的pi配位来尝试。提出的醌类配位网络和稳定的醌类方法在磁学、传感、催化、解毒和给药方案方面具有潜在的应用前景。参与本项目的学生将在合成和光谱方法、x射线晶体学以及电化学技术在基础和技术上重要的化学过程中的应用方面获得广泛的专业知识。

Dwight Sweigart, Brown University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program for the synthesis and study of supramolecular coordination networks generated by the self-assembly of metallic and organometallic molecules. The networks will be based on pi-bonded quinone complexes of transition metals such as manganese, iron, and ruthenium. These networks are electrochemically active and feature a wide range of accessible designs and architectures. Initial goals include the synthesis of materials that incorporate large pores, nanotubes, and interdigitated pi-pi networks. This project also includes the stabilization and study of quinone methides, which are highly reactive molecules of enormous importance in the biosynthesis of melanin and lignin, the action of anti-tumor drugs, and the metabolic oxidation of food additives such as BHT. The stabilization of quinone methides will be attempted by pi-coordination to transition metals. The proposed quinonoid coordination networks and the stabilized quinone methides have potential applications in magnetics, sensing, catalysis, detoxification and drug delivery protocols. Students working on this project will gain broadly-based expertise in synthetic and spectroscopic methods, X-ray crystallography and in the application of electrochemical techniques to fundamental and technologically important chemical processes.