U.S.-Korea Cooperative Research on Physical and Synthetic Studies of Organometallic Electrophiles

美韩有机金属亲电子试剂物理与合成研究合作

• 批准号: 9312709
• 负责人: Dwight Sweigart
• 金额: $ 3.89万
• 依托单位: Brown University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-03-15 至 1999-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9312709&HistoricalAwards=false
• 关键词: U.S.; Korea; Cooperative; Research; Physical

9312709 Sweigart This award provides funds to permit Dr. Dwight A. Sweigart, Department of Chemistry, Brown University, to pursue with Dr. Young K. Chung, Department of Chemistry, Seoul National University, Korea, for 24 months, a program of cooperative research involving physical and synthetic studies of organometallic electrophiles. The project will include both organometallic synthesis and electrochemistry. The synthetic studies will involve the use of manganese to (1) convert arenes to difunctionalized optically pure cyclohexadienes and (2) produce new functionalized derivatives of indoles, steroids, and natural products related to vitamins D and K. The electrochemical part of the research is designed to study the reactivity of 17- and 19-electron organometallic radicals with respect to ligand substitution and other transformations. The proposed research, if successful, will be of significant interest to a range of chemists, including those concerned with organic synthesis in the natural products and drug fields. The PI and his Korean collaborator are highly respected chemists in the fields of this research. Their expertise is complementary. Dr. Chung's group is expert in a wide range of synthetic procedures and will be responsible for perhaps two thirds of the synthetic work. The PI's group will do perhaps one third of the synthetic work and most of the electrochemical and computer work. The collaborators will be assisted by three U.S. graduate students supported by this grant and several Korean graduate students. This project is relevant to the objectives of the U.S.- Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation in the project is supported by the Korea Science and Engineering Foundation (KOSEF). This project adds an international cooperative dimension to the PI's research under NSF Grant No. CHE-8821588. ***

小行星9312709 该奖项提供资金，允许德怀特·A博士。布朗大学化学系的Sweigart博士与Young K. Chung，韩国首尔国立大学化学系，为期24个月，涉及有机金属亲电体的物理和合成研究的合作研究计划。 该项目将包括有机金属合成和电化学。 合成研究将涉及使用锰来（1）将芳烃转化为双官能化的光学纯环己二烯和（2）生产吲哚、类固醇和与维生素D和K相关的天然产物的新官能化衍生物。 研究的电化学部分旨在研究17-和19-电子有机金属自由基的反应性，配体取代和其他转换。 这项研究如果成功，将引起一系列化学家的极大兴趣，包括那些关注天然产物和药物领域有机合成的化学家。 PI和他的韩国合作者是该研究领域备受尊敬的化学家。 他们的专业知识是互补的。 钟博士的小组是各种合成程序的专家，将负责大约三分之二的合成工作。 PI的小组将完成大约三分之一的合成工作，以及大部分的电化学和计算机工作。 合作者将得到三名美国研究生和几名韩国研究生的协助。 该项目与美国的目标有关- 韩国合作科学计划，旨在通过科学信息，思想，技能和技术的交流以及通过互利问题的合作来提高美国和韩国科学家和工程师之间的合作水平。 韩国对该项目的参与得到了韩国科学和工程基金会的支持。 这个项目增加了一个国际合作的层面，PI的研究下，美国国家科学基金会批准号CHE-8821588。 ***