Incorporating High-Field NMR Spectroscopy Throughout the Undergraduate Chemistry Curriculum

吸引许多本科生学习理科的原因是它的实验性质；他们在实践中学习。在化学及相关领域，核磁共振波谱学可以说是结构测定和动态测量中最发达、应用最广泛的实验技术之一。近年来，核磁共振光谱学对化学教育产生了巨大的影响，因为高场光谱仪在美国国家科学基金会的支持下越来越多地提供给本科院校。为了加强整个化学课程，吸引和留住更多的理工科学生，并更好地为这些学生在科学领域的研究生工作和就业做好准备，德保罗大学在其四年的课程中纳入了动手高场FT-NMR光谱。这个项目是模仿类似的nsf资助的项目，这些项目在其他地方已经非常有效地利用核磁共振光谱作为教学工具的全部力量（Davis-UE9751056, Ball-DUE9950413, Liotta-DUE0126678）。通过改编自文献（主要来自J. Chem.）的实验，各级课程的学生都能亲身体验核磁共振波谱学。编辑)或在德保罗发展。在普通化学中，学生使用质子解耦碳核磁共振来确定简单同分异构体碳氢化合物的结构，并观察电负性原子对化学位移的影响。在有机化学中，质子核磁共振和多维技术被用来确定未知和反应产物的结构，特别是新的单体和共聚物。物理化学、仪器分析、中间无机和生物化学的研究生和高年级学生使用核磁共振波谱来确定结构（二氢化物和二氢有机金属配合物）和评估动态过程（平衡、酮-烯醇互变异构、氢键、酵母代谢）。通过越来越复杂的实验，学生们学会欣赏核磁共振光谱的全部力量，同时也培养他们解决问题和批判性思维的能力，并提高他们对化学的整体理解和每个分支学科的相关性。

Chemistry (12) The attraction for many undergraduate students to science is the experimental nature of it; they learn by doing. In chemistry and related fields, NMR spectroscopy is arguably one of the most well-developed and broadly applicable experimental techniques for structure determination and dynamic measurements. In recent years, NMR spectroscopy has had an enormous impact on chemistry education as high field spectrometers become more available to undergraduate institutions through NSF support. In order to strengthen the overall chemistry curriculum, attract and retain more science students, and better prepare those students for graduate work and employment in the sciences, DePaul University is incorporating hands-on high field FT-NMR spectroscopy throughout its four-year program. This project is modeled after similar NSF-funded programs that have been extremely effective elsewhere at exploiting the full power of NMR spectroscopy as a teaching tool (Davis-UE9751056, Ball-DUE9950413, Liotta-DUE0126678). Students at all levels of the curriculum experience NMR spectroscopy first-hand, through experiments that have been adapted from the literature (primarily from J. Chem. Ed.) or developed at DePaul. In general chemistry, students use proton-decoupled carbon NMR to determine the structure of simple isomeric hydrocarbons and observe the effect of electronegative atoms on chemical shift. In organic chemistry, proton NMR and multidimensional techniques are used to determine the structure of unknowns, and reaction products, especially novel monomers and copolymers. Research students and upper level students in physical chemistry, instrumental analysis, intermediate inorganic, and biochemistry use NMR spectroscopy for both structure determination (of dihydride and dihydrogen organometallic complexes) and to evaluate dynamic processes (equilibrium, keto-enol tautomerism, hydrogen bonding, yeast metabolism). Through progressively more sophisticated experiments, students learn to appreciate the full power of NMR spectroscopy while also developing their problem solving and critical thinking skills, and enhancing their overall understanding of chemistry and the relatedness of each subdiscipline.