MRI: Acquisition of a 400 MHz NMR Spectrometer for the Cooperating Colleges of Greater Springfield

在主要研究仪器计划(MRI)的这一奖项和化学研究仪器计划(CRIF)的支持下，新英格兰西部大学将获得一台400 MHz核磁共振光谱仪。该仪器将安置在西北欧大学，并与合作的大斯普林菲尔德学院(CCGs)财团共享用于研究和教学。CCGs联盟由方圆10英里范围内的8所成员机构组成：美国国际学院、海湾路径学院、榆树学院、霍利奥克社区学院、斯普林菲尔德学院、斯普林菲尔德技术社区学院、新英格兰西部大学和韦斯特菲尔德州立大学。该仪器将用于有机、无机和环境化学领域的本科生研究项目。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。该仪器将是联盟机构的本科生进行的教学和研究的一个组成部分。该建议旨在加强研究，特别是在下列领域：(A)研究苯环氧酮作为潜在的基于活性的蛋白质激酶探针模板(斯普林菲尔德学院)；(B)合成和开发用作骨替代品的超支化星形聚合物(WNE)；(C)扩大蒙脱土K10粘土(WNE)的范围；(D)通过生物催化还原研究取代的酮酸酯和酮酰胺的动态动力学拆分(斯普林菲尔德理工学院)；(E)合成和开发用于检测水和土壤中有机磷农药的小分子传感器(WNE)；(F)合成和研究立方烷衍生物(WNE)的热稳定性；(G)合成和研究聚电解质(WNE)；和(H)测定二次氢同位素对烷烃碘化平衡常数的影响(Elms College)。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Western New England University will acquire a 400 MHz NMR spectrometer. The instrument will be housed at WNEU and shared for research and teaching with the Cooperating Colleges of Greater Springfield (CCGS) consortium. The CCGS consortium is comprised of eight member institutions within a 10-mile radius: American International College, Bay Path College, Elms College, Holyoke Community College, Springfield College, Springfield Technical Community College, Western New England University, and Westfield State University. The instrument will be used in undergraduate research projects in areas of organic, inorganic and environmental chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument will be an integral part of teaching as well as research performed by undergraduate students in the consortium institutions. The proposal is aimed at enhancing research especially in areas such as (a) investigating phenyl epoxyenones as potential activity-based probe templates for protein kinases (Springfield College); (b) synthesizing and developing hyperbranched star polymers for use as bone substitutes (WNE); (c) broadening the scope of Montmorillonite K10 clay (WNE) ; (d) studying dynamic kinetic resolution of substituted keto esters and ketoamides via biocatalytic reduction (Springfield Tech Community College); (e) synthesizing and developing small molecule sensors for the detection of organophosphate pesticides in water and soil (WNE); (f) synthesizing and investigating the thermal stability of cubane derivatives (WNE); (g) synthesizing and investigating polyelectrolytes (WNE); and (h) determining secondary deuterium isotope effect on the equilibrium constant for the iodination of alkanes (Elms College).