MRI: Acquisition of a 400 MHz NMR Spectrometer for the Cooperating Colleges of Greater Springfield

在主要研究仪器计划（MRI）的支持下，西新英格兰大学将获得400 MHz NMR光谱仪。该仪器将被安置在WNEU，并与大斯普林菲尔德合作学院（CCGS）财团共享研究和教学。CCGS联盟由10英里半径内的八个成员机构组成：美国国际学院、海湾路径学院、榆树学院、霍利奥克社区学院、斯普林菲尔德学院、斯普林菲尔德技术社区学院、西部新英格兰大学和韦斯特菲尔德州立大学。该仪器将用于有机，无机和环境化学领域的本科生研究项目。 一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。该仪器将成为教学的一个组成部分，以及由大学生在联盟机构进行的研究。该提案旨在加强研究，特别是在以下领域：（a）研究苯基环氧烯酮作为蛋白激酶的潜在活性探针模板（Springfield College）;（B）合成和开发用作骨替代物（WNE）的超支化星星聚合物;（c）拓宽Montreal K10粘土（WNE）的范围;（d）研究经生物催化还原的取代酮酯和酮酰胺的动态动力学拆分（e）合成和开发用于检测水和土壤中有机磷农药的小分子传感器;（f）合成和研究立方烷衍生物（WNE）的热稳定性;（g）合成和研究聚电解质（WNE）;和（h）测定仲氘同位素对烷烃碘化平衡常数的影响（Elms学院）。

With this award from the Major Research Instrumentation Program (MRI) and support from the Chemistry Research Instrumentation Program (CRIF), Western New England University will acquire a 400 MHz NMR spectrometer. The instrument will be housed at WNEU and shared for research and teaching with the Cooperating Colleges of Greater Springfield (CCGS) consortium. The CCGS consortium is comprised of eight member institutions within a 10-mile radius: American International College, Bay Path College, Elms College, Holyoke Community College, Springfield College, Springfield Technical Community College, Western New England University, and Westfield State University. The instrument will be used in undergraduate research projects in areas of organic, inorganic and environmental chemistry. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument will be an integral part of teaching as well as research performed by undergraduate students in the consortium institutions. The proposal is aimed at enhancing research especially in areas such as (a) investigating phenyl epoxyenones as potential activity-based probe templates for protein kinases (Springfield College); (b) synthesizing and developing hyperbranched star polymers for use as bone substitutes (WNE); (c) broadening the scope of Montmorillonite K10 clay (WNE) ; (d) studying dynamic kinetic resolution of substituted keto esters and ketoamides via biocatalytic reduction (Springfield Tech Community College); (e) synthesizing and developing small molecule sensors for the detection of organophosphate pesticides in water and soil (WNE); (f) synthesizing and investigating the thermal stability of cubane derivatives (WNE); (g) synthesizing and investigating polyelectrolytes (WNE); and (h) determining secondary deuterium isotope effect on the equilibrium constant for the iodination of alkanes (Elms College).