SGER: Feasibility of High Gradient Magnetic Implants for Targeted Drug Delivery

摘要提案标题：SGER：高梯度磁性植入体用于靶向药物递送的可行性提案编号：CTS-0314157主要研究者：James Ritter机构： 这项研究的目的是将磁性颗粒结合到药物载体中，并使用磁场将药物引导到特定部位。 该项目将建立在PI在高梯度磁分离（HGMS）概念方面的专业知识基础上，以确定使用磁增强靶向药物递送作为可行治疗工具的可行性。 虽然已经发展了描述铁磁流体液滴在流动流中的滞留的一般唯象理论，但是还没有理论工作来探索使用磁场用于靶向药物递送的局限性。 第一个目标是从理论上确定使用铁磁线局部增强含药物纳米颗粒通过动脉时的力的可行性和局限性。 将探讨各种条件下的模拟。 感兴趣的参数包括线磁特性、线直径、流体速度和血液粘度。 就更广泛的影响而言，这一概念有可能将药物靶向特定位置，从而减少总体剂量并减少潜在的副作用。 还将开展对研究生和本科生的传统指导。 该项目的新奇在于确定使用电产生的磁场来指导药物输送的可行性。 如果成功，该项目可能会导致一种新的技术，用于有效地提供更高浓度的药物，用于治疗癌症，血栓和其他医疗条件

AbstractProposal Title: SGER: Feasibility of High Gradient Magnetic Implants for Targeted Drug DeliveryProposal Number: CTS-0314157Principal Investigator: James RitterInstitution: University of South CarolinaThe objective of the proposed research is to incorporate magnetic particles into drug carriers and direct the drug to a specific site using a magnetic field. This project will build on the PI's expertise in high gradient magnetic separation (HGMS) concepts to determine the feasibility of a using magnetically enhanced targeted drug delivery as a viable therapeutic tool. Although a general phenomenological theory to describe the retention of a ferrofluid drop in a flowing stream has been developed, no theoretical work has been doen to explore the limitations of the use of magnetic fields for targeted drug delivery. The first objective is to determine theoretically the feasibility and limitations of using ferromagnetic wires to locally enhance the force on a drug-containing nanoparticle as it travels through the artery. Simulations over a wide range of conditions will be explored. Parameters of interest include wire magnetic properties, wire diameter, fluid velocity, and blood viscosity. In terms of the broader impacts, this concept has the potential to target drugs to specific locations, thus reducing overall dosage and reducing potential side effects. The traditional mentoring of graduate and undergraduate students will also be carried out. The novelty of this project is to determine the feasibility of using electrically-generated magnetic fields for directing drug delivery. If successful, the project may lead to a new technique for effectively delivering increased con.centrations of drugs for use in the treatment of cancer, blood clots, and other medical conditions