NER: Ferromagnetic Seeding for Non-Invasive Magnetic Drug Targeting

建议标题：NER：用于非侵入性磁性药物靶向的铁磁种子建议编号：CTS-0508391首席研究员：James RitterInstitution：南卡罗来纳大学本建议是对NSF 04-043纳米级科学与工程倡议的响应，NER类。该项目的目标是确定一种名为铁磁播种的新概念的可行性和局限性，用于在人体内对药物或辐射进行磁靶向。直径不超过100纳米的超顺磁性粒子将被用来增强磁性药物载体粒子(MDCP)或放射性粒子在体内特定位置的作用力，从而使其保持在体内的特定位置。在肿瘤上，这种纳米尺度的磁性药物靶向(MDT)植入物将是非侵入性的，只需要使用外部磁铁、磁性种子和MDCP。提出了三项任务来演示概念验证。首先，将设计并进行体外实验，以验证这样一个假设，即小的超顺磁性纳米颗粒有能力捕获代理毛细血管组织中更大的磁性药物载体颗粒。其次，将PI最近开发的二维数学模型进一步扩展到三维，并用体外实验进行验证。这些模型将有助于从根本上了解这种非侵入性MDT方法中的潜在、控制和限制现象。第三，利用新的声化学技术，将制备出具有最优物理和生物性能的超顺磁性纳米颗粒种子，用于MDT。这项工作的更广泛的影响在于将这些想法应用于其他重要的生物医学应用，如在交变磁场的影响下使用磁性纳米颗粒作为加热剂来治疗肿瘤，或者在外部磁场的影响下通过局部栓塞或坏死受影响的毛细血管来使肿瘤饥饿。

AbstractProposal Title: NER: Ferromagnetic Seeding for Non-invasive Magnetic Drug TargetingProposal Number: CTS-0508391Principal Investigator: James RitterInstitution: University of South CarolinaThis proposal was received in response to Nanoscale Science and Engineering initiative, NSF 04-043, category NER. The objective of this project is to determine the feasibility and limitations of a new concept, called ferromagnetic seeding, for magnetic targeting of drugs or radiation in the human body. Superparamagnetic particles, no larger than 100 nm in diameter, will be used to enhance the force on and hence retention of magnetic drug carrier particles (MDCPs) or radioactive particles at a specified site in the body. On a tumor, this nanoscale magnetic drug targeting (MDT) implant will be non-invasive and only require the use of an external magnet, the magnetic seeds and the MDCPs. Three tasks are proposed to demonstrate proof-of-concept. First, in vitro experiments will be devised and carried out to verify the hypothesis that small superparamagnetic nanoparticles have the ability to capture the far larger magnetic drug carrier particles in surrogate capillary tissue. Second, the two-dimensional mathematical model recently developed by the PI will be further extended to three dimensions and validated with the in vitro experiments. The models will help gain a fundamental understanding of the underlying, controlling and limiting phenomena in this non-invasive MDT approach. Third, superparamagnetic nanoparticle seeds will be prepared with the most optimal physical and biological properties for MDT using novel sonochemical techniques. The broader impact of this work lies in the application of these ideas to other important biomedical applications, like in the treatment of tumors by using magnetic nanoparticles as hyperthermia agents under the influence of an alternating magnetic field or by using them to starve a tumor through localized embolization or necrosis of affected capillaries under the influence of an external magnetic field.