Developing Supramolecular Synthesis: From Molecular Function to Supramolecular Assembly

本研究的重点包括三个目标。首先，设计、合成非对称双位超分子试剂（SR’s），用于促进两种不同氢键官能团之间的超分子偶联反应，而不考虑组分的大小和形状。其次，设计并合成了四种不同类型的可作为季际和季际超分子组装位点的SR。第三，作为第一目标，所开发的不对称双位SR将作为不同碗状分子和大环的非共价偶联试剂。由此产生的宿主的内部体积将是不同的，不对称的分子胶囊可以在同一个腔内容纳两个不同的客人。通过这个奖项，有机和大分子化学项目支持了堪萨斯州立大学化学系的Christer B. Aakeroy博士的研究。Aakeroy博士将把他的工作重点放在开发能够以高产量构建具有理想和可预测连接的超分子结构的超分子试剂库上。该项目还为本科生和研究生的跨学科培训提供了一个极好的场所，项目的结果可能对材料设计和生物模拟的制备产生更广泛的影响。

The focus of this research involves three goals. First, asymmetric ditopic supramolecular reagents (SR's) will be designed, synthesized and used to facilitate supramolecular coupling reactions between two different hydrogen-bonding functional groups irrespective of the size and shape of the components. Second, four different classes of SR's that can act as assembly sites for quaternary and quinternary supermolecules will be designed and synthesized. Third, the asymmetric ditopic SR's developed, as the first goal, will be used as non-covalent coupling reagents of different bowl-shaped molecules and macrocycles. The internal volume in the resulting hosts will be varied and asymmetric molecular capsules that can incorporate two different guests within the same cavity will be prepared.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Christer B. Aakeroy of the Department of Chemistry at Kansas State University. Dr. Aakeroy will focus his work on developing libraries of supramolecular reagents that are capable of constructing, in high yield, supramolecular architectures with desirable and predictable connectivities The project also provides an excellent venue for the interdisciplinary training of undergraduate and graduate students and results from the project could have broader impact for materials design and for the preparation of biological mimics.