Developing Supramolecular Synthesis: From Molecular Function to Supramolecular Assembly

发展超分子合成：从分子功能到超分子组装

• 批准号: 0316479
• 负责人: Christer Aakeroy
• 金额: $ 39.5万
• 依托单位: Kansas State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316479&HistoricalAwards=false
• 关键词: Developing; Supramolecular; Synthesis; Molecular; Function

The focus of this research involves three goals. First, asymmetric ditopic supramolecular reagents (SR's) will be designed, synthesized and used to facilitate supramolecular coupling reactions between two different hydrogen-bonding functional groups irrespective of the size and shape of the components. Second, four different classes of SR's that can act as assembly sites for quaternary and quinternary supermolecules will be designed and synthesized. Third, the asymmetric ditopic SR's developed, as the first goal, will be used as non-covalent coupling reagents of different bowl-shaped molecules and macrocycles. The internal volume in the resulting hosts will be varied and asymmetric molecular capsules that can incorporate two different guests within the same cavity will be prepared.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Christer B. Aakeroy of the Department of Chemistry at Kansas State University. Dr. Aakeroy will focus his work on developing libraries of supramolecular reagents that are capable of constructing, in high yield, supramolecular architectures with desirable and predictable connectivities The project also provides an excellent venue for the interdisciplinary training of undergraduate and graduate students and results from the project could have broader impact for materials design and for the preparation of biological mimics.

本研究的重点涉及三个目标。 首先，不对称的ditopic超分子试剂（SR）的设计，合成和使用，以促进两个不同的氢键官能团之间的超分子偶联反应，而不管组件的大小和形状。 第二，四个不同类别的SR的，可以作为组装位点的四元和五元超分子将被设计和合成。 第三，作为第一个目标，所开发的不对称双配位SR将用作不同碗形分子和大环的非共价偶联试剂。 所得主体中的内部体积将是变化的，并且将制备可以在同一腔中包含两种不同客体的不对称分子胶囊。有了这个奖项，有机和大分子化学计划正在支持克里斯特B博士的研究。堪萨斯州立大学化学系的Aakeroy说。 Aakeroy博士将专注于开发能够以高产率构建具有理想和可预测连接性的超分子结构的超分子试剂库 该项目还为本科生和研究生的跨学科培训提供了一个很好的场所，该项目的结果可能对材料设计和生物模拟物的制备产生更广泛的影响。