New Directions in Selectivity via Palladium and Indium Mediated Methodology

通过钯和铟介导的方法实现选择性的新方向

• 批准号: 0316618
• 负责人: Gregory Cook
• 金额: --
• 依托单位: North Dakota State University Fargo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316618&HistoricalAwards=false
• 关键词: New; Directions; Selectivity; via; Palladium

The foci of this research are three fold. First, Pd-catalyzed isomerization and kinetic allylic substitution will be used to prepare oxazolines and vicinal diamines. Second, In-catalyzed atom transfer cyclization methodology will be studied. Third, In-mediated allylation of aldehydes and imines, utilizing Pd-catalysis to generate reactive indium complexes, will be developed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Gregory R. Cook in the Department of Chemistry at North Dakota State University. Dr. Cook will focus his work on developing synthetic methodology for the palladium-catalyzed synthesis of aminoalcohols and diamines and on the use of indium catalysis to develop eco-friendly processes for organic synthesis. The project could have broader impact for the pharmaceutical industry and for green chemistry in general. The project also presents an excellent venue for the training of graduate students.

本研究的重点有三个方面。 首先，钯催化的异构化和动力学烯丙基取代将用于制备恶唑啉和邻二胺。 第二，铟催化的原子转移环化反应方法学研究。 第三，铟介导的醛和亚胺的烯丙基化，利用钯催化生成反应性铟络合物，将被开发。库克在北达科他州州立大学化学系。 库克博士将专注于开发钯催化合成氨基醇和二胺的合成方法，以及使用铟催化开发生态友好的有机合成工艺。 该项目可能对制药业和一般的绿色化学产生更广泛的影响。 该项目还为研究生的培训提供了一个极好的场所。