Amide and Thioamide Macrocyclic Anion Receptors

酰胺和硫代酰胺大环阴离子受体

• 批准号: 0316623
• 负责人: Kristin Bowman-James
• 金额: $ 40.5万
• 依托单位: University of Kansas Center for Research Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316623&HistoricalAwards=false
• 关键词: Amide; Thioamide; Macrocyclic; Anion; Receptors

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Dr. Kristin Bowman-James of the University of Kansas at Lawrence to investigate the coordination chemistry of anions using new classes of macrocyclic receptors. Specific recognition of negatively charged molecular ions, which are abundant species in the environment and biological systems, is a major challenge. This project will identify the binding patterns for a variety of anions at the molecular level and also explore the sensor capabilities of modified receptors. The ultimate objective of this project is to establish a framework for the strategic design of selective binding agents and sensors.The goal of this project is to explore the basic chemistry underlying the selective binding of anions with receptors that possess both amine and amide or amine and thioamide functionalities. The strategy is to examine systematically the influence of selected aspects of the ligand design on anion coordination: hydrogen bonding capability (amides vs. thioamides), ligand preorganization (syn or anti orientation of amide/thioamide groups), size, dimensionality (monocyclic vs. bicyclic), and charge (neutral vs. quaternized amines). Attachment of electrochemical and fluorescent probes will be used to explore the capability of these receptors as anion sensors. Substrates will include small inorganic anions, such as halides, pseudohalides and other halide-containing anions as well as oxo anions, with both trigonal and tetrahedral structures. Because of current concerns about groundwater contamination by anions such as nitrate, phosphate, and fluoride, as well as homeland security issues involving cyanide and arsenate, this study will lay the groundwork for future applications in anion sensing and removal. Both underrepresented groups and women have been involved in this research and active recruitment of underrepresented groups will continue.

这个无机、生物无机和有机金属化学项目的奖项支持堪萨斯大学劳伦斯分校的Kristin Bowman-James博士利用新型大环受体研究阴离子的配位化学。带负电荷的分子离子是环境和生物系统中丰富的物种，对其进行特异性识别是一个重大挑战。该项目将在分子水平上确定各种阴离子的结合模式，并探索修饰受体的传感器能力。该项目的最终目标是为选择性结合剂和传感器的战略设计建立一个框架。该项目的目标是探索阴离子与胺和酰胺或胺和硫酰胺功能受体选择性结合的基本化学基础。该策略是系统地检查配体设计的选定方面对阴离子配位的影响：氢键能力（酰胺与硫酰胺），配体预组织（酰胺/硫酰胺基团的顺取向或反取向），尺寸，维度（单环与双环）和电荷（中性胺与季铵化胺）。电化学探针和荧光探针的连接将用于探索这些受体作为阴离子传感器的能力。底物将包括小的无机阴离子，如卤化物、假卤化物和其他含卤化物的阴离子以及氧阴离子，具有三角形和四面体结构。由于目前人们对硝酸盐、磷酸盐和氟化物等阴离子污染地下水的担忧，以及涉及氰化物和砷酸盐的国土安全问题，本研究将为阴离子传感和去除的未来应用奠定基础。代表人数不足的群体和妇女都参与了这项研究，将继续积极征聘代表人数不足的群体。