MRI: Acquisition of a CCD X-ray Diffractometer

MRI：获取 CCD X 射线衍射仪

• 批准号: 0321214
• 负责人: Kevin Klausmeyer
• 金额: $ 21.08万
• 依托单位: Baylor University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0321214&HistoricalAwards=false
• 关键词: MRI; Acquisition; CCD; ray; Diffractometer

With support from the Major Research Instrumentation (MRI) Program, the Department of Chemistry and Biochemistry at Baylor University will acquire a X-ray diffractometer with CCD detector. This equipment will enhance research in a number of areas including the following: a) the synthesis and characterization of new organometallic species, especially anionic compounds that may be linked together for the formation of dendrimers, polymers and other supramolecular species; b) the study of the chemistry of 'half sandwich' monocarbollide complexes of transition metals; c) the design of new vascular targeting agents for cancer chemotherapy; and d) the development of chemically modified electrode arrays for sensing ionic contaminants in aqueous matrices. The X-ray diffractometer allows accurate and precise measurements of the full three dimensional structure of a molecule, including bond distances and angles, and it provides accurate information about the spatial arrangement of the molecule relative to the neighboring molecules. These studies will have an impact in a number of areas, especially medicinal chemistry and materials chemistry.

在主要研究仪器(MRI)计划的支持下，贝勒大学化学和生物化学系将获得一台带有CCD探测器的X射线衍射仪。这一设备将加强以下领域的研究：a)新的有机金属物种的合成和表征，特别是可连接在一起形成树枝状大分子、聚合物和其他超分子物种的阴离子化合物；b)过渡金属的‘半夹心’单碳化合物络合物的化学研究；c)设计用于癌症化疗的新的血管靶向药物；d)开发用于检测水基质中离子污染物的化学修饰电极阵列。X射线衍射仪可以精确和精确地测量分子的全部三维结构，包括键的距离和角度，并提供关于分子相对于邻近分子的空间排列的准确信息。这些研究将在多个领域产生影响，特别是药物化学和材料化学。