SBIR Phase II: Advanced Optical Instruments for Monitoring Asthma

这个小型企业创新研究第二阶段项目将开发一种基于激光的呼吸仪，用于检测和监测儿童和成人的哮喘。第一阶段的工作证明了建造一台基于红外激光吸收光谱的机器的可行性，该机器能够测量呼出的一氧化氮(ENO)和呼出的二氧化碳(Eco2)水平，以评估哮喘适应症的呼吸道炎症并监测治疗依从性。在第二阶段项目中，用于电子和数据处理的专用硬件设计以及用户友好的定制编写软件将集成到一个紧凑的系统中，该系统用于监测呼吸道炎症，具有成本效益、高度敏感、实时和可靠。该项目的商业应用是在生物医学设备和仪器领域。

This Small Business Innovation Research Phase II project will develop a laser based breathmeter for detecting and monitoring asthma in children and adults. The Phase I work proved the feasibility of constructing a machine, based on infrared laser absorption spectroscopy, that is capable of measuring exhaled nitric oxide (eNO) and exhaled carbon dioxide (eCO2) levels to evaluate airway inflammation for indications of asthma and to monitor treatment compliance. In the Phase II project, a dedicated hardware design for electronics and data processing plus user-friendly custom written software will be integrated into a compact system that is cost effective, highly sensitive, real-time, and reliable for monitoring airway inflammation. The commercial application of this project is in the area of biomedical devices and instrumentation.