US-Jordan Cooperative Research: Second Harmonic Imaging of Cells Using Silicon Nanoparticles

项目描述：本项目支持伊利诺伊大学厄巴纳-香槟分校物理系Munir Nayfeh教授与约旦大学安曼分校物理系Laila Abu-Hassan博士的合作研究。他们计划研究在Nayfeh博士的实验室合成的纳米粒子的半导体性质，以及它们作为生物传感器在医疗诊断和医疗保健服务中的应用。他们将专注于高发光硅纳米颗粒的开发和表征及其作为超灵敏生物标记物的潜在用途。这包括用于细胞二次谐波成像的硅纳米粒子的合成、表征和应用，重点是探索用于细胞研究中检测的薄膜中的硅纳米粒子的二次谐波生成。他们计划开发一种有效的方法，将硅纳米颗粒涂在柔性衬底上，包括用于随后的荧光或二次谐波成像的细胞。这将有助于理解半导体纳米材料中的量子尺寸效应，特别是硅纳米颗粒中光致发光和二次谐波产生的机制。项目范围：该项目为PI正在进行的研究提供了一个国际维度，该研究是在当前的NSF奖- bes -0118053下进行的。该项目将对生物光子学和生物传感器领域的发展产生重大影响。它可能导致开发新颖、可靠、廉价、敏感和环境安全的生物传感器，在生物医学研究中具有重要应用。该项目将在国际范围内培养生物光子学跨学科领域的研究生和博士后。

0323307 NayfehDescription: This project supports a cooperative research between Professor Munir Nayfeh, Department of Physics, University of Illinois at Urbana-Champaign, Illinois and Dr. Laila Abu-Hassan, Department of Physics, University of Jordan, Amman, Jordan. They plan to study the semiconductor nature of nanoparticles that are synthesized at Dr. Nayfeh's laboratory, and their use as biosensors with applications in medical diagnosis and healthcare delivery. They will focus on the development and characterization of highly luminescent silicon nanoparticles and their potential use as ultrasensitive biological markers. This includes the synthesis, characterization and application of silicon nanoparticles for the second harmonic imaging of cells, with a focus on exploring the second harmonic generation of silicon nanoparticles in thin films for detection in cell research. They plan to develop efficient methods for coating silicon nanoparticles on flexible substrates including cells for subsequent fluorescent or second harmonic imaging of the cells. This will help in developing the understanding of quantum size effects in semiconductor nanoscale materials, in general, and specifically, the mechanisms of photoluminescence and second harmonic generation in silicon nanoparticles.Scope: The project provides an international dimension to research the PI is conducting under a current NSF award-BES-0118053. This project may have a significant impact on the progress in the field of biophotonics and biosensors. It may result in developing novel, reliable, cheap, sensitive and environmentally safe biosensors with significant applications in biomedical research. This project will provide for training graduate students and postdoctoral fellows in this interdisciplinary field of biophotonics, within an international setting.