US-Jordan Cooperative Research: Second Harmonic Imaging of Cells Using Silicon Nanoparticles

美国-约旦合作研究：使用硅纳米粒子对细胞进行二次谐波成像

• 批准号: 0323307
• 负责人: Munir Nayfeh
• 金额: --
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2006-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0323307&HistoricalAwards=false
• 关键词: US; Jordan; Cooperative; Research; Second

0323307 NayfehDescription: This project supports a cooperative research between Professor Munir Nayfeh, Department of Physics, University of Illinois at Urbana-Champaign, Illinois and Dr. Laila Abu-Hassan, Department of Physics, University of Jordan, Amman, Jordan. They plan to study the semiconductor nature of nanoparticles that are synthesized at Dr. Nayfeh's laboratory, and their use as biosensors with applications in medical diagnosis and healthcare delivery. They will focus on the development and characterization of highly luminescent silicon nanoparticles and their potential use as ultrasensitive biological markers. This includes the synthesis, characterization and application of silicon nanoparticles for the second harmonic imaging of cells, with a focus on exploring the second harmonic generation of silicon nanoparticles in thin films for detection in cell research. They plan to develop efficient methods for coating silicon nanoparticles on flexible substrates including cells for subsequent fluorescent or second harmonic imaging of the cells. This will help in developing the understanding of quantum size effects in semiconductor nanoscale materials, in general, and specifically, the mechanisms of photoluminescence and second harmonic generation in silicon nanoparticles.Scope: The project provides an international dimension to research the PI is conducting under a current NSF award-BES-0118053. This project may have a significant impact on the progress in the field of biophotonics and biosensors. It may result in developing novel, reliable, cheap, sensitive and environmentally safe biosensors with significant applications in biomedical research. This project will provide for training graduate students and postdoctoral fellows in this interdisciplinary field of biophotonics, within an international setting.

0323307 Nayfeh描述：该项目支持伊利诺伊大学厄巴纳-香槟分校物理系Munir Nayfeh教授和约旦大学物理系Laila Abu-Hassan博士（安曼）之间的合作研究。 他们计划研究Nayfeh博士实验室合成的纳米颗粒的半导体性质，以及它们作为生物传感器在医疗诊断和医疗保健方面的应用。 他们将专注于高发光硅纳米粒子的开发和表征及其作为超灵敏生物标记物的潜在用途。 这包括硅纳米粒子的合成，表征和应用，用于细胞的二次谐波成像，重点是探索硅纳米粒子在薄膜中的二次谐波产生，用于细胞研究中的检测。 他们计划开发有效的方法，将硅纳米颗粒涂覆在柔性基底上，包括细胞，用于随后的细胞荧光或二次谐波成像。 这将有助于发展的量子尺寸效应在半导体纳米材料的理解，在一般情况下，特别是在硅nanoparticle.Scope的光致发光和二次谐波产生的机制：该项目提供了一个国际层面的研究PI正在进行根据目前的NSF奖BES-0118053。 该项目可能对生物光子学和生物传感器领域的进展产生重大影响。 它可能导致开发新的，可靠的，廉价的，敏感的和环境安全的生物传感器在生物医学研究中具有重要的应用。该项目将在国际范围内为生物光子学这一跨学科领域的研究生和博士后研究员提供培训。