Plasticity and cell type-specific function of OTUB1 in infection (A05)

OTUB1 在感染中的可塑性和细胞类型特异性功能 (A05)

• 批准号: 163805947
• 金额: --
• 依托单位: Institut für Medizinische Mikrobiologie und Krankenhaushygiene
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2010
• 资助国家: 德国
• 起止时间: 2009-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/163805947?language=en
• 关键词: Plasticity; cell; type; specific; function

A05 defined that the deubiquitinating enzyme (DUB) CYLD aggravates listeriosis by inhibiting protective signaling pathways, whereas the DUB A20 ameliorates listeriosis by enabling the survival of CD8+ memory T cells. Employing a newly established conditional OTUB1-/- mouse strain, A05 identified that the DUB OTUB1 regulates JAK-, TLR11- and YB-1-mediated signaling. In the next funding period, A05 will focus on OTUB1 in (1) T cells, (2) DCs, (3) macrophages and (4) hepatocytes in listeriosis to determine the cell type-specific molecular function (cooperation with B19, B26) and plasticity (cooperation with A01, A04, A30N, Z01) of OTUB1 under inflammatory conditions.

A05定义了去泛素化酶（DUB）CYLD通过抑制保护性信号传导途径来抑制线粒体病，而DUB A20通过使CD 8+记忆T细胞存活来改善线粒体病。采用新建立的条件性OTUB 1-/-小鼠品系，A05鉴定出DUB OTUB 1调节JAK、TLR 11和YB-1介导的信号传导。在下一个资助期内，A05将重点关注OTUB 1在阿尔茨海默病中的（1）T细胞、（2）DC、（3）巨噬细胞和（4）肝细胞，以确定OTUB 1在炎症条件下的细胞类型特异性分子功能（与B19、B26合作）和可塑性（与A01、A04、A30 N、Z 01合作）。