CTLA-4 (CD152)-induced signaling pathways as regulators of CD8+ T lymphocytes (B14)

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To prevent immunopathology, differentiation of CD8+ T cells is tightly controlled by inhibitory receptors such as CTLA-4. Project B14, in collaboration with B16, identified by iTRAQ mass spectrometry novel signal transduction pathways downstream of CTLA-4 that will be further characterized in the 3rd funding period. In this respect, B14 will connect changes in cellular metabolism with altered T cell functions. The role of CTLA-4-mediated TCF-1 regulation in memory formation will be analyzed in a Listeria infection model in collaboration with A05. Furthermore, B14 will analyze the impact of CTLA-4 on JAML in the context of co-stimulation and adhesion in collaboration with B08 and B12.