Drosophila Acp Evolution

果蝇 Acp 进化

• 批准号: 0327049
• 负责人: David Begun
• 金额: --
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0327049&HistoricalAwards=false
• 关键词: Drosophila; Acp; Evolution

In Drosophila, males transfer a large number of accessory gland proteins (Acps) to females along with sperm. These proteins have several effects on female physiology. They also affect patterns of sperm use (female flies store sperm in specialized organs). Furthermore, these proteins may affect the outcome of sperm competition, which occurs when a female mates with multiple males. Acps show highly unusual patterns of evolution and variation, perhaps as a result of natural selection. The proposed work uses DNA sequence analysis and quantitative measures of transcription at Acps to measure variation in amino acid sequence and gene expression within Drosophila melanogaster and between D. melanogaster and three closely related species. The goal of the work is to reveal the evolutionary mechanisms leading to the unusually high rates of evolution in these genes.Males and females interact in each generation to reproduce. Understanding the cooperation and conflicts that arise as result of these interactions is an important area of biology. Acps are likely to be important proteins mediating the mechanistic and evolutionary aspects of male-female interactions. Therefore, revealing the evolutionary mechanisms underlying variation in these genes may provide general insights into such interactions in animals.

在果蝇中，雄性将大量的附属腺蛋白（Acps）随精子沿着转移给雌性。 这些蛋白质对女性生理有几种影响。 它们还影响精子的使用模式（雌性果蝇将精子储存在专门的器官中）。此外，这些蛋白质可能会影响精子竞争的结果，这种情况发生在雌性与多个雄性交配时。Acps显示出极不寻常的进化和变异模式，这可能是自然选择的结果。 本研究利用DNA序列分析和Acps转录的定量方法来测量果蝇体内和果蝇与果蝇之间氨基酸序列和基因表达的差异。和三个相近的物种。 这项工作的目标是揭示导致这些基因异常高的进化速率的进化机制。雄性和雌性在每一代中相互作用以繁殖。理解这些相互作用所产生的合作和冲突是生物学的一个重要领域。 Acps可能是重要的蛋白质介导的机制和进化方面的男性女性的相互作用。 因此，揭示这些基因变异背后的进化机制可能会为动物中这种相互作用提供一般性的见解。