DISSERTATION RESEARCH: Population Genetics of Genes Important in Female Responses to Mating in Drosophila melanogaster

论文研究：果蝇雌性交配反应中重要基因的群体遗传学

• 批准号: 0407781
• 负责人: David Begun
• 金额: $ 1.2万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0407781&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Population; Genetics; Genes

In Drosophila and many other animal and plant taxa, interactions between males and females that occur after mating can have huge impacts on reproductive success. For example, Drosophila seminal fluid proteins cause increases in female egg-laying rate, female death rate, and reductions in female re-mating. The goal of this work by Dr. David Begun and Mara Lawniczak is to gain an understanding of the female side of post-mating interactions. Female-expressed genes contributing to the outcome of sperm competition will be investigated genetically and molecularly. The evolutionary forces acting on these genes will be analyzed using population genetics. Sexual selection can be a major force in driving evolutionary change in some organisms, including humans. The proposed research will contribute to identification of mechanisms of sexual selection, of biochemical classes of proteins involved in male-female interactions, and of the population genetic signatures of genes under sexual selection. All of these results may find broader application in the study of human reproductive biology.

在果蝇和许多其他动植物类群中，交配后发生的雄性和雌性之间的相互作用可能会对繁殖成功产生巨大影响。例如，果蝇精液蛋白导致雌性产卵率增加，雌性死亡率增加，雌性重新交配减少。David Begin博士和Mara LawNiczak博士的这项工作的目标是了解交配后互动中女性的一面。女性表达的影响精子竞争结果的基因将被从遗传学和分子方面进行研究。作用于这些基因的进化力量将使用群体遗传学进行分析。性选择可能是推动包括人类在内的某些生物体进化变化的主要力量。拟议的研究将有助于确定性别选择的机制，涉及男女相互作用的生化蛋白质类别，以及性别选择下基因的群体遗传特征。所有这些结果都可能在人类生殖生物学研究中得到更广泛的应用。