Environmental Remediation Through Self-Assembly and Applications to Environmental Sensor Development

通过自组装进行环境修复及其在环境传感器开发中的应用

• 批准号: 0329311
• 负责人: Vijay John
• 金额: $ 10万
• 依托单位: Tulane University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0329311&HistoricalAwards=false
• 关键词: Environmental; Remediation; Through; Self; Assembly

John, Vijay T.Tulane University"Environmental Remediation through Self-Assembly and Applications to Environmental Sensor Development"The objective of this research is to develop a process for environmental remediation of aqueous streams containing aromatic compounds. The process involves incorporating well-known technologies with new science. Surfactant micelles will be first used to concentrate organic contaminants (typically phenols and aromatic amines) in aqueous streams, in a version of the well-studied micellar enhanced ultrafiltration technology (MEUF). The next step will be to polymerize these contaminants within the micelles using oxidative enzymes such as horseradish peroxidase. The resulting conjugated polymers are themselves very useful in coatings technologies, and in applications to electrooptics. The third step is to encapsulate the micelle-polymer assembly within the pore structure of mesoporous silicas (and titanias). This will result in useful polymer-ceramic nanocomposites where functionality of the encapsulated materials can be utilized to develop robust sensor materials that are photoluminescent. The encapsulation of enzymes through this route will also be evaluated in the development of novel chemo-biosensors.Broader impacts Excellent interdisciplinary training for both undergraduates and graduate students will be provided. The combination of spectroscopy, microscopy and scattering techniques that the students will be exposed to, will be an invaluable research experience. Tulane University operates a unique Coordinated Instrumentation Facility where centralized instrumentation and expertise allow excellent student training. The PI's are fully committed to providing educational opportunities, and have a strong record of working towards such objectives with formalized programs such as the Louisiana Alliance for Minority Participation in Research (LAMP). The research is the continuation of a collaboration at Tulane that has produced several Ph.D. graduates and has provided undergraduate research experience to over 10 students. From a technical prospective, the exploratory research phase will evaluate the feasibility of transforming environmental contaminants to useful, high value products. The process of enzyme entrapment in mesoporous silicas will be used to encapsulate phosphotriesterase. Thin films of such enzyme containing silicas will be used to develop a sensor for the detection of nerve agent surrogates such as paraoxon.

John，Vijay T.Tulane大学“通过自组装进行环境修复和应用于环境传感器开发“本研究的目的是开发一种用于含有芳香族化合物的水流的环境修复的方法。这一过程涉及将众所周知的技术与新科学相结合。表面活性剂胶束将首先用于浓缩水流中的有机污染物（通常是酚类和芳香胺），这是一种经过充分研究的胶束增强超滤技术（MEUF）。下一步将是使用氧化酶如辣根过氧化物酶将这些污染物包裹在胶束中。所得的共轭聚合物本身在涂料技术和电光应用中非常有用。第三步是将胶束-聚合物组装体封装在介孔二氧化硅（和二氧化钛）的孔结构内。这将产生有用的聚合物-陶瓷纳米复合材料，其中封装材料的功能性可用于开发光致发光的鲁棒传感器材料。 通过这一途径对酶的包封也将在新型化学生物传感器的开发中进行评估。更广泛的影响将为本科生和研究生提供优秀的跨学科培训。学生将接触到的光谱学、显微镜和散射技术的结合将是一次宝贵的研究经历。杜兰大学经营着一个独特的协调仪器设施，集中的仪器和专业知识允许优秀的学生培训。PI完全致力于提供教育机会，并通过正式的计划（如路易斯安那州少数民族参与研究联盟（LAMP））努力实现这些目标。这项研究是杜兰大学合作的延续，该合作已经产生了几位博士学位。毕业生，并提供了本科研究经验，以超过10名学生。从技术角度来看，探索性研究阶段将评估将环境污染物转化为有用的高价值产品的可行性。酶在介孔二氧化硅中的包埋过程将用于包埋磷酸三酯酶。这种含有二氧化硅的酶薄膜将用于开发一种传感器，用于检测神经毒剂替代品，如对氧磷。