Per- and Polyfluoroalkyl Substances (PFAS) in Marine Fish and Shellfish: A biomonitoring tool for PFAS remediation and a metric for potential human exposure through seafood consumption

海洋鱼类和贝类中的全氟烷基物质和多氟烷基物质 (PFAS)：PFAS 修复的生物监测工具以及人类通过海鲜消费潜在接触的指标

• 批准号: 10472968
• 负责人: Celia Y Chen
• 金额: $ 5万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-11 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10472968
• 关键词: Acids; Address; Adverse effects; Affect; Air; Animals; Archives; Beds; Biological Monitoring; Bivalvia; Blood; Carbon ion; Child; Cholesterol; Collaborations; Communities; Consumption; Data; Development; Diet; Ecosystem; Effectiveness; Endocrine Disruptors; Environment; Environmental Pollution; Epidemiologist; Exposure to; Film; Fisheries; Fishes; Fresh Water; Future; Habits; Harvest; Health; Health Policy; Human; Individual; Ingestion; Intervention; Investigation; Ion Exchange Resins; Knowledge; Liver; Maine; Measurement; Military Personnel; Monitor; New England; New Hampshire; Outcome; Pattern; Policies; Poly-fluoroalkyl substances; Population; Pregnant Women; Public Health; Pump; Regulation; Research; Research Project Grants; Risk; Risk Assessment; Role; Sampling; Scientist; Seafood; Services; Shellfish; Site; Soil; Source; Stream; Sulfonic Acids; Surface; Surveys; System; Thyroid Gland; Time; Tissue Sample; Tissues; Toxic effect; Training Activity; United States; United States Environmental Protection Agency; Water; Water Supply; Water consumption; aqueous; base; bioaccumulation; cancer risk; college; contaminated drinking water; contaminated water; dietary; drinking water; effectiveness evaluation; epidemiology study; exposed human population; exposure pathway; exposure route; ground water; perfluorohexane; perfluorooctane; perfluorooctanoic acid; prevent; public health priorities; remediation; substance use; tool

PROJECT SUMMARY With concerns about human exposure to per- and polyfluoroalkyl substances (PFASs) on the rise, regional data about PFASs in various environmental media are needed to inform enforceable and protective standards for common routes of exposure, including seafood consumption. PFASs are persistent environmental contaminants of particular concern for vulnerable and sensitive populations, including children and pregnant women. Four PFASs are commonly detected in blood from United States (US) residents: perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS). Animal and epidemiologic studies support a role for PFAS effects on the thyroid, liver, cholesterol, and even cancer risk. Human exposure to PFASs occurs primarily through ingestion, notably via PFAS contaminated drinking water and diet. These contaminants pose a regional as well as national threat to surface water and drinking water supplies with detections occurring in 49 states. PFASs in fish and shellfish, particularly in freshwater ecosystems, are recognized as an important dietary source of exposure, but data regarding exposures from marine sourced seafood are limited, hindering the development of health protective standards. In the northeastern United States (US), where an abundance of PFAS contamination sites have been identified and seafood consumption rates tend to be high relative to other regions of the US, marine species comprise a considerable share of the market. In New Hampshire (NH), the PFAS landscape is rapidly evolving with implementation of regulatory limits on drinking water supplies, investigation and remediation efforts at affected sites, and ongoing efforts to monitor exposed communities. As regulations of PFAS use evolve and remediation commences at contaminated sites, seafood monitoring will be integral to evaluating effectiveness of policies and remediation activities. There is an urgent need to collect human exposure data in order to provide critical information to understand the PFAS exposure-health outcome relationship. The proposed research encompasses both measurements of PFASs in regionally sourced, commonly consumed marine seafood species, and an assessment of local seafood consumption habits to help meet this need. The research will be conducted by a highly interdisciplinary team of scientists (marine biologists, epidemiologists, toxicologists, environmental chemists) involving a collaboration between the NH Department of Environmental Services and Dartmouth College. The project will leverage a unique archive of existing fish and shellfish tissue samples harvested throughout the Gulf of Maine (GOM), as well as new samples collected in Great Bay (GB) adjacent to a PFAS contamination site at the Pease Air Force Base. Furthermore, the proposed research will take advantage of the start of active PFAS remediation at the Pease Air Force Base to evaluate remedial effectiveness based on PFAS concentrations in the neighboring GB. The research project is proposed to provide time critical data to support timely action to protect public health in the GOM region.

项目总结